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Treatment of poor graft function after allogeneic hematopoietic cell transplantation with a booster of CD34-selected cells infused without conditioning

Bone Marrow Transplantation volume 49, pages 720–721 (2014)Cite this article

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Graft failure (GF) after allo-SCT is a serious complication with high mortality.1, 2 Discrimination between rejection and poor graft function (PGF) can be made by chimerism analysis. In rejection, chimerism status is mixed, with the presence of recipient cells, whereas full donor chimerism is present in PGF. In patients with rejection, a second transplant preceded by a conditioning regimen should be considered.1, 2, 3

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References

  1. Rondón G, Saliba RM, Khouri I, Giralt S, Chan K, Jabbour E et al. Long-term follow-up of patients who experienced graft failure postallogeneic progenitor cell transplantation. Results of a single institution analysis. Biol Blood Marrow Transplant 2008; 14: 859–866.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Schriber J, Agovi M, Ho V, Ballen KK, Bacigalupo A, Lazarus HM et al. Second unrelated donor hematopoietic cell transplantation for primary graft failure. Biol Blood Marrow Transplant 2005; 16: 1099–1106.

    Article  Google Scholar 

  3. Platzbecker U, Binder M, Schmid C, Rutt C, Ehninger G, Bornhäuser M . Second donation of hematopoietic stem cells from unrelated donors for patients with relapse or graft failure after allogeneic transplantation. Haematologica 2008; 93: 1276–1278.

    Article  PubMed  Google Scholar 

  4. Nakamae H, Storer B, Sandmaier BM, Maloney DG, Davis C, Corey L et al. Cytopenias after day 28 in allogeneic hematopoietic cell transplantation: impact of recipient/donor factors, transplant conditions and myelotoxic drugs. Haematologica 2011; 96: 1838–1845.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Larocca A, Piaggio G, Podestà M, Pitto A, Bruno B, Di Grazia C et al. Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation. Haematologica 2006; 91: 935–940.

    PubMed  Google Scholar 

  6. Remberger M, Ringdén O, Ljungman P, Hägglund H, Winiarski J, Lönnqvist B et al. Booster marrow or blood cells for graft failure after allogeneic bone marrow transplantation. Bone Marrow Transplant 1998; 22: 73–78.

    Article  CAS  PubMed  Google Scholar 

  7. Dreger P, Suttorp M, Haferlach T, Loffler H, Schmitz N, Schroyens W . Allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for treatment of engraftment failure after bone marrow transplantation. Blood 1993; 81: 1404–1407.

    CAS  PubMed  Google Scholar 

  8. Milone G, Tornello A, Leotta S, Poidomani M, Mercurio S, Farsaci B et al. CD34+ selected haematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy as effective treatment for graft failure. Bone Marrow Transplant 2005; 35: 521–522.

    Article  CAS  PubMed  Google Scholar 

  9. Mohty M, Faucher C, Chabannon C, Vey N, Stoppa AM, Ladaique P et al. CD34(+) immunoselected cells for poor graft function following allogeneic BMT. Cytotherapy 2000; 2: 367–370.

    Article  CAS  PubMed  Google Scholar 

  10. Robin M, Tabrizi R, Mohty M, Furst S, Michallet M, Bay J-O et al. Allogeneic haematopoietic stem cell transplantation for myelofibrosis: a report of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC). Br J Haematol 2011; 152: 331–339.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department Of Hematology, National University Hospital, Copenhagen, Denmark

    B Askaa, L Vindeløv & H Sengeløv

  2. Department of Clinical Immunology, National University Hospital, Copenhagen, Denmark

    A Fischer-Nielsen & E K Haastrup

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  1. B Askaa
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  2. A Fischer-Nielsen
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  3. L Vindeløv
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Correspondence to H Sengeløv.

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Askaa, B., Fischer-Nielsen, A., Vindeløv, L. et al. Treatment of poor graft function after allogeneic hematopoietic cell transplantation with a booster of CD34-selected cells infused without conditioning. Bone Marrow Transplant 49, 720–721 (2014). https://doi.org/10.1038/bmt.2014.5

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