Abstract
Several Cord Blood (CB) Bank studies suggested that ethnicity impaired CB unit (CBU) qualification. The Bone Marrow Donors Worldwide registries present an over-representation of unrelated donors (UD) from Northwestern European descent. This raises the question of equality of access to hematopoietic stem cells transplant, especially in the Mediterranean zone, which has taken in many waves of immigration. The aim of our study is to address whether, in the Marseille CB Bank, CBU qualification rate is impaired by geographic origin. The study compared biological characteristics of 106 CBU disqualified for total nucleated cell (TNC) count (dCBU) and 136 qualified CBU in relation to registry enrichment and haplotype origin. A high proportion (>80%) of both dCBU and CBU had at least one non-European haplotype and enrich CB and UD registries to a higher extent than those with two European haplotypes (P<0.001). No difference was observed between TNC count and volume according to geographic origin. Our study shows that diverse Mediterranean origins do not have an impact on the CBU qualification rate. Partnership with Mediterranean birth clinics with highly trained staff is a reasonable option to increase the HLA diversity of CB Bank inventories and to improve the representation of minorities.
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Acknowledgements
This work was supported in part by Agence de la Biomédecine through funding ‘Research and Graft – 2013’ ADB/EBe-DLE. We thank the generous donors and their families for donating their cord blood for public use. The authors acknowledge all the personnel at the Hôpital de la conception birth clinic, at the Institut Paoli-Calmettes cell therapy facility and at the Etablissement Français du Sang Alpes Méditerranée department of Histocompatibility and Immuno-genetics for their contribution to the daily routine of the Marseille CBB. We also thank P.A. Gouraud for his advice on statistical analyses.
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Bordoni, C., Magalon, J., Gilbertas, C. et al. Cord blood collection and banking from a population with highly diverse geographic origins increase HLA diversity in the registry and do not lower the proportion of validated cord blood units: experience of the Marseille cord blood bank. Bone Marrow Transplant 50, 531–535 (2015). https://doi.org/10.1038/bmt.2014.314
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DOI: https://doi.org/10.1038/bmt.2014.314