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Quality of Life

Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study

Bone Marrow Transplantation volume 49, pages 709–716 (2014)Cite this article

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Abstract

The purpose of this multicenter study was to compare the long-term impact of a preparative regimen with either BUBU or TBI on health status and quality of life (QoL) in childhood acute leukemia survivors treated with hematopoietic SCT (HSCT). Two-hundred and forty patients were included. Sixty-six had received BU, while 174 had received TBI. Median follow-up from HSCT was 10.1 years. Multivariate analyses were performed to assess the occurrence of late effects according to treatment. QoL was assessed in 130 adults using SF-36 questionnaires. Patients developed fewer late complications after BU (2.35 vs 3.01, P=0.03) while the risk to present with at least one complication was equivalent in both groups (87.9% after BU and 93.1% after TBI, P=0.66). Detailed multivariate analyses revealed a lower risk of height growth failure (OR=0.2), cataract (OR=0.1) and iron overload (OR=0.2) after BU, and an increased risk of overweight (OR=3.9) and alopecia (OR=11.2). SF-36 mental and physical composite scores were similar in both treatment groups and proved significantly lower than French norms. Late effects induced by BU might differ from those experienced after TBI. Although less frequent, they are still of considerable importance and may affect patients’ QoL.

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Acknowledgements

The authors would like to thank Barbara Play, Anderson Loundou, Delphine Orbicini and Virginie Villes for their assistance with the LEA database. This work was supported by the French National Clinical Research Program, the French National Cancer Institute and the Pediatric Hematology PACA Network.

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Authors and Affiliations

  1. Department of Pediatric Hematology-Oncology, La Timone Children’s Hospital, Marseille, France

    F Bernard, I Herrmann, C Galambrun, V Barlogis, H Chambost & G Michel

  2. Department of Public Health -EA 3279 Research Unit, University Hospital of Marseille, Aix-Marseille University, Marseille, France

    P Auquier, J Berbis, F Garnier & G Michel

  3. Department of Pediatric Hematology-Oncology, Brabois Children’s Hospital, Vandoeuvre-Les-Nancy, France

    A Contet & P Chastagner

  4. Department of Pediatric Hematology-Oncology, L’Archet II Hospital, Nice, France

    M Poiree

  5. Department of Pediatric Hematology-Oncology, CIC Inserm 501, University Hospital of Clermont Ferrand, Clermont-Ferrand, France

    F Demeocq & J Kanold

  6. Department of Pediatric Hematology-Oncology, University Hospital of Grenoble, Grenoble, France

    D Plantaz

  7. Department of Pediatric Hematology-Oncology, Arnaud de Villeneuve Hospital, Montpellier, France

    N Sirvent

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  1. F Bernard
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Correspondence to F Bernard.

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Bernard, F., Auquier, P., Herrmann, I. et al. Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study. Bone Marrow Transplant 49, 709–716 (2014). https://doi.org/10.1038/bmt.2014.3

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  • DOI: https://doi.org/10.1038/bmt.2014.3

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