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TLI-based reduced-intensity conditioning hematopoietic SCT for children and adolescents with high-risk nonmalignant disorders

Bone Marrow Transplantation volume 50, pages 452–454 (2015)Cite this article

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Allogeneic hematopoietic SCT (HSCT) is the only curative therapy for several nonmalignant disorders in children and young adults. Limitations of HSCT in nonmalignant disorders include increased rates of graft failure (GF), infections, GVHD and early/late irreversible complications of conditioning regimens.1, 2 Recent studies using non-myeloablative or reduced-intensity conditioning (RIC) seek to limit side effects by using less intense, better tolerated regimens. There are emerging data on the use of TLI as part of the conditioning regimen in adults with malignant disease and its potential protective role against the development of post-transplant GVHD.3 There are very limited data on the use of TLI in children with nonmalignant diseases.4, 5

In an effort to achieve successful, stable donor engraftment and minimize early and late toxicities in high-risk patients with nonmalignant hematological disorders, we adopted a TLI-based RIC regimen before HLA-matched related HSCT.

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Acknowledgements

The authors thank Dua'a AL-Hamdan for help in data retrieval and Daliya Remawi for statistical analysis.

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Authors and Affiliations

  1. Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center (KHCC), Amman, Jordan

    A A Hussein, E Khattab & A Al-Zaben

  2. Department of Radiotherapy, King Hussein Cancer Center (KHCC), Amman, Jordan

    A Al-Mousa

  3. Pediatric Stem Cell Transplant Program, Monroe Carell Jr Children’s Hospital at Vanderbilt, Nashville, TN, USA

    H Frangoul

Authors
  1. A A Hussein
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  2. A Al-Mousa
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  3. E Khattab
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  4. A Al-Zaben
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  5. H Frangoul
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Correspondence to A A Hussein.

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Hussein, A., Al-Mousa, A., Khattab, E. et al. TLI-based reduced-intensity conditioning hematopoietic SCT for children and adolescents with high-risk nonmalignant disorders. Bone Marrow Transplant 50, 452–454 (2015). https://doi.org/10.1038/bmt.2014.268

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