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Supportive Care

The impact of improved JACIE standards on the care of related BM and PBSC donors

Bone Marrow Transplantation volume 50, pages 244–247 (2015)Cite this article

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Abstract

Discrepancies exist between the care of unrelated donors (UDs) and related donors (RDs), particularly regarding medical suitability criteria, consenting procedures and donor follow-up. Changes to the most recent JACIE standards have addressed these issues. We studied 208 RDs who underwent PBSC or BM donation in a single centre during 2004–2013 to determine the impact of regulatory changes on donor care, and assessed the safety and efficacy of stem cell donation in donors not meeting UD medical suitability criteria. We observed significant improvements in donor consenting procedures (P=0.003) and donor follow-up (P=0.007) after stipulations in these areas were introduced. We saw a higher incidence of serious adverse events (SAEs) in RDs not meeting UD suitability criteria (P=0.018), and a higher incidence of SAEs in donors ⩾60 years (P=0.020). Haematopoietic progenitor cell donation is less safe in RDs who do not meet UD criteria for medical suitability. Although changes to JACIE standards have improved practice, development of specific medical suitability for RDs and guidelines around ‘grey areas’ where risks to a donor are unclear or theoretical, will be important in improving RD safety and standardising practice.

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References

  1. O'Donnell PV, Pedersen TL, Confer DL, Rizzo JD, Pulsipher MA, Stroncek D et al. Practice patterns for evaluation, consent, and care of related donors and recipients at hematopoietic cell transplantation centers in the United States. Blood 2010; 115: 5097–5101.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Coluccia P, Crovetti G, Del Fante C, Dallavalle FM, Laszlo D, Ferremi P et al. Screening of related donors and peripheral blood stem cell collection practices at different Italian apheresis centres. Blood Transfus 2012; 10: 440–447.

    PubMed  PubMed Central  Google Scholar 

  3. Clare S, Mank A, Stone R, Davies M, Potting C, Apperley JF et al. Management of related donor care: a European survey. Bone Marrow Transplant 2010; 45: 97–101.

    Article  CAS  PubMed  Google Scholar 

  4. Sacchi N, Costeas P, Hartwell L, Hurley CK, Raffoux C, Rosenmayr A et al. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant 2008; 42: 9–14.

    Article  CAS  PubMed  Google Scholar 

  5. Halter J, Kodera Y, Ispizua AU, Greinix HT, Schmitz N, Favre G et al. Severe events in donors after allogeneic hematopoietic stem cell donation. Haematologica 2009; 94: 94–101.

    Article  PubMed  Google Scholar 

  6. WHO Notify Report: Exploring vigilance notification for organs tissues and cells 2011. Available at http://www.notifylibrary.org/sites/default/files/BOOK%20NOTIFY.pdf.

  7. Kodera Y, Yamamoto K, Harada M, Morishima Y, Dohy H, Asano S et al. PBSC collection from family donors in Japan: a prospective survey. Bone Marrow Transplant 2014; 49: 195–200.

    Article  CAS  PubMed  Google Scholar 

  8. Wiersum-Osselton JC, van Walraven SM, Bank I, Lenselink AM, Fibbe WE, van der Bom JG et al. Clinical outcomes after peripheral blood stem cell donation by related donors: a Dutch single-center cohort study. Transfusion 2013; 53: 96–103.

    Article  PubMed  Google Scholar 

  9. Joint Accreditation Committee—ISCT & EBMT. International Standards for Cellular Therapy Product Collection Processing and Adminstration. 5th edn. Available at http://www.jacie.org Accessed on 9 October 2013.

  10. van Walraven SM, Nicoloso-de Faveri G, Axdorph-Nygell UA, Douglas KW, Jones DA, Lee SJ et al. Family donor care management: principles and recommendations. Bone Marrow Transplant 2010; 45: 1269–1273.

    Article  CAS  PubMed  Google Scholar 

  11. Halter JP, van Walraven SM, Worel N, Bengtsson M, Hagglund H, Nicoloso de Faveri G et al. Allogeneic hematopoietic stem cell donation-standardized assessment of donor outcome data: a consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Bone Marrow Transplant 2013; 48: 220–225.

    Article  CAS  PubMed  Google Scholar 

  12. WMDA. International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries standards W. International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries. Available at http://www.worldmarrow.org/fileadmin/Committees/STDC/20140101-STDC-WMDA_Standards.pdf. Accessed on 9 October 2013.

  13. Niederwieser D, Gentilini C, Hegenbart U, Lange T, Moosmann P, Ponisch W et al. Transmission of donor illness by stem cell transplantation: should screening be different in older donors? Bone Marrow Transplant 2004; 34: 657–665.

    Article  CAS  PubMed  Google Scholar 

  14. Lysak D, Koristek Z, Gasova Z, Skoumalova I, Jindra P . Efficacy and safety of peripheral blood stem cell collection in elderly donors; does age interfere? J Clin Apher 2011; 26: 9–16.

    Article  PubMed  Google Scholar 

  15. Richa E, Papari M, Allen J, Martinez G, Wickrema A, Anastasi J et al. Older age but not donor health impairs allogeneic granulocyte colony-stimulating factor (G-CSF) peripheral blood stem cell mobilization. Biol Blood Marrow Transplant 2009; 15: 1394–1399.

    Article  CAS  PubMed  Google Scholar 

  16. Vasu S, Leitman SF, Tisdale JF, Hsieh MM, Childs RW, Barrett AJ et al. Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population. Blood 2008; 112: 2092–2100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. de Lavallade H, Ladaique P, Lemarie C, Furst S, Faucher C, Blaise D et al. Older age does not influence allogeneic peripheral blood stem cell mobilization in a donor population of mostly white ethnic origin. Blood 2009; 113: 1868–1869.

    Article  CAS  PubMed  Google Scholar 

  18. Pulsipher M. RDSafe (related donor safety study): a Multi-Institutional Study of HSC Donor Safety and Quality Life by Pulsipher and Switzer. Available at http://www.researchgrantdatabase.com/g/1R01HL085707.

  19. Shaw BE, Ball L, Beksac M, Bengtsson M, Confer D, Diler S et al. Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerations. Bone Marrow Transplant 2010; 45: 832–838.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Anthony Nolan Research Institute, London, UK

    C Anthias, A Madrigal & B E Shaw

  2. UCL Cancer Institute, University College London, London, UK

    C Anthias, A Madrigal & B E Shaw

  3. The Royal Marsden Hospital, Sutton, UK

    M E Ethell, M N Potter & B E Shaw

Authors
  1. C Anthias
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  2. M E Ethell
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  3. M N Potter
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  4. A Madrigal
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  5. B E Shaw
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Correspondence to C Anthias.

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The authors declare no conflict of interest.

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Author Contributions

CA and BES designed the research study; CA performed the research and analysed the data; CA, MEE, MNP, AM and BES wrote the paper.

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Anthias, C., Ethell, M., Potter, M. et al. The impact of improved JACIE standards on the care of related BM and PBSC donors. Bone Marrow Transplant 50, 244–247 (2015). https://doi.org/10.1038/bmt.2014.260

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  • DOI: https://doi.org/10.1038/bmt.2014.260

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