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Safety of stem cell mobilization in donors with sickle cell trait

Bone Marrow Transplantation volume 50, pages 310–311 (2015)Cite this article

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High WBC plays a major role in the pathogenesis of many of the complications seen in patients with sickle cell disease (SCD).1 Individuals with Sickle cell trait may develop SCD-related complications in conditions of severe stress.2 G-CSF increases the WBC and may contribute to some of the complications in individuals with sickle cell trait when used in stem cell mobilization. To the best of our knowledge, only one small study3 assessed the safety of the mobilization of stem cells in individuals with sickle cell trait. Herein, we aimed to compare mobilization adverse events between donors with and without sickle cell trait.

Consecutive donors for BMT in our center, Sultan Qaboos University Hospital during the period January 2007–March 2013 were reviewed for inclusion. Donors with evidence of sickle cell trait in the pre-donation hemoglobin electrophoresis or HPLC were included in this study. Twelve donors with sickle cell trait were found. Similar numbers of age and gender matched controls with normal HPLC were selected. We used filgrastim 10 μg/kg subcutaneously daily for 6 days for the mobilization of stem cells. The PBSC were collected on day 6 two hours after the last dose of G-CSF on the day of mobilization. In our center, the target count used is 6 × 106 CD34+ cells per kg recipient.

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Acknowledgements

We thank the nurses in the transplant and apheresis units, transplant coordinators and bone marrow transplant recipients and donors for their participation in the study.

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Authors and Affiliations

  1. Department of Hematology, Sultan Qaboos University Hospital, Muscat, Oman

    M Al-Khabori, F Al-Ghafri, S Al-Kindi, A Z Al-Riyami, K Al-Farsi, M Al-Huneini, D Dennison, H Khan & S Daar

  2. Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman

    A Al-Rawas

Authors
  1. M Al-Khabori
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  2. F Al-Ghafri
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  3. S Al-Kindi
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  4. A Z Al-Riyami
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  5. K Al-Farsi
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  6. M Al-Huneini
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  7. D Dennison
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  8. A Al-Rawas
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  9. H Khan
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  10. S Daar
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Correspondence to M Al-Khabori.

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The authors declare no conflict of interest.

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Al-Khabori, M., Al-Ghafri, F., Al-Kindi, S. et al. Safety of stem cell mobilization in donors with sickle cell trait. Bone Marrow Transplant 50, 310–311 (2015). https://doi.org/10.1038/bmt.2014.252

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