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Improvement of high serum levels of biomarkers of endothelial injury after allogeneic hematopoietic SCT with pre-existing severe hepatitis using recombinant human soluble thrombomodulin

Bone Marrow Transplantation volume 49, pages 1444–1445 (2014)Cite this article

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Veno-occlusive disease of the liver, referred to as sinusoidal obstruction syndrome (SOS), is a severe complication of allogeneic hematopoietic SCT (allo-HSCT). The condition is characterized by hyperbilirubinemia, fluid retention and painful hepatomegaly presenting 1 month after HSCT. SOS occurs in 5.3% of HSCTs, and severe cases rapidly deteriorate to multiple organ failure with an overall fatality rate of 18.4%.1

Usually, ursodeoxycholic acid (UDCA) and heparin are used to prevent SOS.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Internal Medicine, St Marianna University of Medicine, Kawasaki, Japan

    T Saito, Y Inoue, K Sato, Y Tsuruoka, M Takahashi & I Miura

  2. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University of Medicine, Kawasaki, Japan

    R Shigefuku, H Ikeda & C Okuse

Authors
  1. T Saito
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  2. Y Inoue
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  3. K Sato
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  6. H Ikeda
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  7. C Okuse
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  8. M Takahashi
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  9. I Miura
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Corresponding author

Correspondence to Y Inoue.

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This manuscript was made according to the Declaration of Helsinki.

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Saito, T., Inoue, Y., Sato, K. et al. Improvement of high serum levels of biomarkers of endothelial injury after allogeneic hematopoietic SCT with pre-existing severe hepatitis using recombinant human soluble thrombomodulin. Bone Marrow Transplant 49, 1444–1445 (2014). https://doi.org/10.1038/bmt.2014.156

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  • DOI: https://doi.org/10.1038/bmt.2014.156

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