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Acute Leukemia

Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP

Bone Marrow Transplantation volume 49, pages 1266–1268 (2014)Cite this article

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Abstract

Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients received auto-SCT and rapidly died from ATL. Out of 17 allo-SCT (4 myeloablative, 13 reduced intensity), 6 are still alive (4 were in CR1 at SCT). Eleven patients died within 2 years, eight from relapse/progression and three from transplant toxicity. Six of seven informative patients who lived >12 months had chronic GVHD. Overall these results indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients.

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Acknowledgements

K Raj, P Fields Guys and St Thomas' and Kings College Hospitals, London, UK [721] 6. A Nagler, Tel-Hashomer, Tel Aviv, Israel [754] 4. K Cwynarski, Royal Free Hospital, London, UK [216] 3. A Bazarbachi, American University of Beirut, Medical Center, Beirut, Lebanon [369] 1. A Buzyn, F Suarez, OHermine, Hôpital Necker, University of Paris, France [160] 1. M Mohty, Hôpital Saint-Antoine, Paris, France [213] 1. Sridhar Chaganti, Queen Elizabeth Hospital, Birmingham, UK 1. E Kanfer, Hammersmith Hospital, London, UK [205] 1. JH Veelken, Leiden University Hospital, Netherlands [203] 1. M Potter, Royal Marsden Hospital, London, Surry, UK [218] 1. JY Cahn, Hopital A. Michallon, Grenoble, France [270] 1.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine, Medical Center, American University of Beirut, Beirut, Lebanon

    A Bazarbachi

  2. Department of Haematology, Royal Free Hospital, London, UK

    K Cwynarski

  3. LWEBMT Paris Office, Hôpital Saint-Antoine, Paris, France

    A Boumendil & H Finel

  4. Department of Haematology, Guys and St Thomas' and Kings College Hospitals, London, UK

    P Fields & K Raj

  5. Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Israel

    A Nagler

  6. Service d’Hématologie clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France

    M Mohty

  7. Universite Pierre & Marie Curie, Paris, France

    M Mohty

  8. Haematology Department, Addenbrookes Hospital, Cambridge University, Cambridge, UK

    A Sureda

  9. Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    P Dreger

  10. Department of Hematology, Hôpital Necker, University of Paris, Paris, France

    O Hermine

  11. Imagine Institute, INSERM U1163 CNRS ERL 8254, Paris, France

    O Hermine

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  1. A Bazarbachi
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Correspondence to A Bazarbachi or K Cwynarski.

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Bazarbachi, A., Cwynarski, K., Boumendil, A. et al. Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP. Bone Marrow Transplant 49, 1266–1268 (2014). https://doi.org/10.1038/bmt.2014.143

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