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Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances

Bone Marrow Transplantation volume 49, pages 1070–1075 (2014)Cite this article

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Abstract

This study aimed to compare the therapeutic effects of single umbilical cord blood transplantation (UCBT) and unmanipulated haploidentical hematopoietic SCT (haplo-HSCT) in childhood hematologic malignances. We enrolled 410 consecutive children who received either single UCBT (n=37) or haplo-HSCT from a family donor (n=373) during the same time period. For each UCBT recipient, three recipients matched for year of HSCT, underlying diseases, disease status and the length of follow-up were randomly selected from the haplo-HSCT cohort. Hematopoietic recovery was significantly faster in haplo-HSCT recipients than in UCBT recipients. The incidence of chronic GVHD was significantly higher in haplo-HSCT recipients. The incidence of CMV-related interstitial pneumonia was higher in UCBT recipients. The haplo-HSCT recipients had better 1-year OS (73.0% vs 56.8%, P=0.048), lower 1-year non-relapse mortality (NRM, 18.0% vs 35.1%, P=0.026) and lower 2-year NRM rates (19.9% vs 35.1%, P=0.044). The relapse- and disease-free survival rates did not differ significantly between the groups. Our results showed that compared with UCBT, unmanipulated haplo-HSCT can improve the outcomes of children with hematologic malignances.

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Acknowledgements

We thank Editage for providing editorial assistance. This work was supported by the Beijing Municipal Science and Technology Program (Grant No. Z111107067311070) and the Key Program of National Natural Science Foundation of China (Grant No. 81230013).

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  1. X-D Mo and X-Y Zhao: These authors contributed equally to this work.

Authors and Affiliations

  1. Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China

    X-D Mo, X-Y Zhao, D-H Liu, Y-H Chen, L-P Xu, X-H Zhang, H Chen, W Han, Y Wang, F-R Wang, J-Z Wang, K-Y Liu & X-J Huang

  2. Peking-Tsinghua Center for Life Sciences, Beijing, China

    X-J Huang

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  1. X-D Mo
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Correspondence to X-J Huang.

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Mo, XD., Zhao, XY., Liu, DH. et al. Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances. Bone Marrow Transplant 49, 1070–1075 (2014). https://doi.org/10.1038/bmt.2014.109

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