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Alopecia areata after HLA-identical BMT from an affected, sibling donor

Bone Marrow Transplantation volume 49, pages 592–594 (2014)Cite this article

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Alopecia areata is an HLA-restricted, T-cell-mediated autoimmune reaction targeting the anagen (growing) hair follicle, which can proceed to total body hair loss (alopecia1 universalis, AU). Experimentally, alopecia areata can be transferred by T cells within human skin grafts in a mouse model, but such investigations were not possible in humans before allo-SCT.1

We previously reported a 48-year-old white man with CML who developed alopecia areata 15 months after receiving a allo-SCT from his HLA-identical brother with alopecia areata.2 We now report a second patient, a 55-year-old white female with AML, who developed alopecia areata 16 months after receiving an allo-SCT, from her brother with AU.

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Authors and Affiliations

  1. Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    S Nadeem, S Hymes & M Duvic

  2. Department of Stem Cell Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    P Kebriaei

  3. Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    L Abruzzo

  4. Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    J L Curry

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  1. S Nadeem
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  2. S Hymes
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  5. J L Curry
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  6. M Duvic
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Correspondence to S Nadeem.

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Nadeem, S., Hymes, S., Kebriaei, P. et al. Alopecia areata after HLA-identical BMT from an affected, sibling donor. Bone Marrow Transplant 49, 592–594 (2014). https://doi.org/10.1038/bmt.2013.212

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