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Stem Cell Procurement

PBSC collection from family donors in Japan: a prospective survey

Bone Marrow Transplantation volume 49, pages 195–200 (2014)Cite this article

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Abstract

Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

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Acknowledgements

We thank R Kodera, K Kawai, T Shimizu and Y Yamada (EPS Co.) for their generous assistance in the course of the survey. The study was partially supported by Health and Labor Sciences Research Grants, Research on Tissue Engineering, Ministry of Health, Labor and Welfare, Japan. JH and AG were in part supported by the Swiss National Foundation grant NRP 63.

Author information

Authors and Affiliations

  1. Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan

    Y Kodera & Y Morishima

  2. Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan

    K Yamamoto

  3. Department of Medicine and Biosystemic Science, Kyushu University, Faculty of Medicine, Fukuoka, Japan

    M Harada

  4. Department of Hematology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan

    H Dohy

  5. Department of Chemistry/Biological Chemistry, Integrative Bioscience and Bioengineering, Advanced Sciences and Engineering, Waseda University, Tokyo, Japan

    S Asano

  6. Department of Life Science and Medical Bioscience, Integrative Bioscience and Bioengineering, Advanced Sciences and Engineering, Waseda University, Tokyo, Japan

    Y Ikeda

  7. Clinical Application Department Center for iPS Cell Research and Application(CiRA), Kyoto University, Kyoto, Japan

    T Nakahata

  8. Department of Hematology, Hokkaido University Hospital, Sapporo, Japan

    M Imamura

  9. Department of Hematology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    K Kawa

  10. Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan

    S Kato

  11. Division of Hematology/Oncology, Okayama University Hospital, Okayama, Japan

    M Tanimoto

  12. Division of Hematology, Jichi Medical University Hospital, Saitama, Japan

    Y Kanda

  13. Division of Hematopoietic Stem Cell Transplantation (Pediatrics), National Cancer Center Hospital, Tokyo, Japan

    R Tanosaki

  14. Ishikawa Red Cross Blood Center, Kanazawa, Japan

    S Shiobara

  15. Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    S W Kim

  16. Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    K Nagafuji

  17. Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan

    M Hino

  18. Department of Hematology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan

    K Miyamura

  19. Department of HSCT Data Management, Nagoya University Graduate School of Medicine, Nagoya, Japan

    R Suzuki

  20. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

    N Hamajima

  21. Translational Research Informatics Center, The Foundation for Biomedical Research and Innovation, Kyoto, Japan

    M Fukushima

  22. Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan

    A Tamakoshi

  23. Department of Medicine, Hematology Unit, University Hospital Basel, Basel, Switzerland

    J Halter

  24. Department of Hematology, University of Kiel, Kiel, Germany

    N Schmitz

  25. Deapartment of Hematology, University Hospital Leipzig, Leipzig, Germany

    D Niederwieser

  26. EBMT Activity Survey Office, University of Basel, Basel, Switzerland

    A Gratwohl

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Correspondence to Y Kodera.

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Author Contributions

YK, KY and MH designed the study and wrote the paper. YM, HD, SA, MI, KK, SK and MT collected and organized the data. YK, RT, SS, SWK, KN, MH, KM and RS supervised the process of data collection. NH, MF and AK performed the statistical analysis. JH, NS, DN and AG consulted with the study concept and reviewed the results.

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Kodera, Y., Yamamoto, K., Harada, M. et al. PBSC collection from family donors in Japan: a prospective survey. Bone Marrow Transplant 49, 195–200 (2014). https://doi.org/10.1038/bmt.2013.147

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