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Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM

Abstract

The matched-control study failed to show a clinical relevant impact of palifermin on intestinal mucositis, although there was a reduced inflammatory response and less febrile neutropenia among patients who had no bacteraemia.

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References

  1. Sonis ST . Oral mucositis. Anti-Cancer Drugs 2011; 22: 607–612.

    Article  CAS  Google Scholar 

  2. Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004; 351: 2590–2598.

    Article  CAS  Google Scholar 

  3. Blijlevens N, de Chateau M, Krivan G, Rabitsch W, Szomor A, Pytlik R et al. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient’s burden. Bone Marrow Transplant 2012; 48: 966–971.

    Article  Google Scholar 

  4. Goldberg JD, Zheng J, Castro-Malaspina H, Jakubowski AA, Heller G, van den Brink MR et al. Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants. Bone Marrow Transplant 2013; 48: 99–104.

    Article  CAS  Google Scholar 

  5. Johansson JE, Hasseus B, Johansson P, Eklof C, Ohman D, Stockelberg D . Gut protection by palifermin during autologous haematopoietic SCT. Bone Marrow Transplant 2009; 43: 807–811.

    Article  CAS  Google Scholar 

  6. Blijlevens NM, Lutgens LC, Schattenberg AV, Donnelly JP . Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy. Bone Marrow Transplant 2004; 34: 193–196.

    Article  CAS  Google Scholar 

  7. De Pauw BE, Deresinski SC, Feld R, Lane-Allman EF, Donnelly JP . Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. A multicenter randomized trial. The Intercontinental Antimicrobial Study Group. Ann Intern Med 1994; 120: 834–844.

    Article  CAS  Google Scholar 

  8. Cancer Therapy Evaluation Program NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0 Online Instructions and Guidelines. https://webapps.ctep.nci.nih.gov/webobjs/ctc/webhelp/welcome_to_ctcae.htm . Accessed May 19, 2009.

  9. Costa SF, Barone AA, Miceli MH, van der Heijden IM, Soares RE, Levin AS et al. Colonization and molecular epidemiology of coagulase-negative Staphylococcal bacteremia in cancer patients: a pilot study. Am J Infect Control 2006; 34: 36–40.

    Article  Google Scholar 

  10. Kennedy HF, Morrison D, Kaufmann ME, Jackson MS, Bagg J, Gibson BE et al. Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient. J Med Microbiol 2000; 49: 367–370.

    Article  CAS  Google Scholar 

  11. Ruescher TJ, Sodeifi A, Scrivani SJ, Kaban LB, Sonis ST . The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies. Cancer 1998; 82: 2275–2281.

    Article  CAS  Google Scholar 

  12. Herbers AH, Blijlevens NM, Donnelly JP, de Witte TJ . Bacteraemia coincides with low citrulline concentrations after high-dose melphalan in autologous HSCT recipients. Bone Marrow Transplant 2008; 42: 345–349.

    Article  CAS  Google Scholar 

  13. Van der Velden WJ, Blijlevens NM, Feuth T, Donnelly JP . Febrile mucositis in haematopoietic SCT recipients. Bone Marrow Transplant 2009; 43: 55–60.

    Article  CAS  Google Scholar 

  14. Panoskaltsis-Mortari A, Taylor PA, Rubin JS, Uren A, Welniak LA, Murphy WJ et al. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury. Blood 2000; 96: 4350–4356.

    CAS  PubMed  Google Scholar 

  15. Ellison CA, Makar BM, Wiseman JM, Gheorghiu I, Taniguchi M, Gartner JG . Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol 2008; 28: 600–615.

    Article  CAS  Google Scholar 

  16. Barazzone C, Donati YR, Rochat AF, Vesin C, Kan CD, Pache JC et al. Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice. Am J Pathol 1999; 154: 1479–1487.

    Article  CAS  Google Scholar 

  17. Yildirim AO, Muyal V, John G, Müller B, Seifart C, Kasper M et al. Palifermin induces alveolar maintenance programs in emphysematous mice. Am J Respir Crit Care Med 2010; 181: 705–717.

    Article  CAS  Google Scholar 

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Acknowledgements

We are indebted to Amgen Netherlands for donating an unrestricted grant.

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Correspondence to A H E Herbers.

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The authors declare no conflict of interest.

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AHEH and NMAB conceived the study, wrote and reviewed the manuscript. JPD and WJFMvdV helped to draft the manuscript. AFJdH performed the statistical analysis.

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Herbers, A., van der Velden, W., de Haan, A. et al. Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM. Bone Marrow Transplant 49, 8–10 (2014). https://doi.org/10.1038/bmt.2013.118

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