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Posaconazole is not superior to itraconazole for fungal prophylaxis in allogeneic blood and marrow transplantation

Bone Marrow Transplantation volume 47, page 1379 (2012)Cite this article

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I read with interest the article by Sánchez-Ortega et al.1 In their discussion, the authors admit several limitations, which significantly discredit the value of the data presented. I note the following additional limitations:

  1. 1)

    The study was done in two different periods of time.

  2. 2)

    There was no sample size calculation.

  3. 3)

    Serum galactomannan was done routinely on all patients twice weekly, which is not the standard practice in many transplant programs.

  4. 4)

    In reading the details of the Methods section, the end point appears to be based on the clinicians’ decision to change antifungal therapy ‘in a real life setting’; rather than probable/proven invasive fungal infection.

  5. 5)

    There were more patients who received reduced intensity conditioning in the posaconazole group than the itraconazole group (P=0.06).

The study was done in two different periods of time.

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References

  1. Sánchez-Ortega I, Patiño B, Arnan M, Peralta T, Parody R, Gudiol C et al. Clinical efficacy and safety of primary antifungal prophylaxis with posaconazole vs itraconazole in allogeneic blood and marrow transplantation. Bone Marrow Transplant 2011; 46: 733–739.

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Authors and Affiliations

  1. Department of Infectious Diseases, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA

    S B Mossad

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  1. S B Mossad
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Correspondence to S B Mossad.

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The author declares no conflict of interest.

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Mossad, S. Posaconazole is not superior to itraconazole for fungal prophylaxis in allogeneic blood and marrow transplantation. Bone Marrow Transplant 47, 1379 (2012). https://doi.org/10.1038/bmt.2012.34

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  • DOI: https://doi.org/10.1038/bmt.2012.34

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