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Post-transplant Events

Factors affecting the development of atrial fibrillation and atrial flutter (AF/AFL) following autologous hematopoietic SCT (auto-HSCT)

Bone Marrow Transplantation volume 48, pages 963–965 (2013)Cite this article

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Abstract

The use of autologous hematopoietic SCT (auto-HSCT) has expanded to include older patients. Increasing age is a well-appreciated risk factor for the development of atrial fibrillation and/or atrial flutter (AF/AFL) in the general population. As more elderly patients undergo auto-HSCT, the risk of developing AF/AFL post transplant may also increase. However, few data evaluating other risk factors for the development of AF/AFL following auto-HSCT exist. Therefore, we performed a retrospective study to determine the incidence of AF/AFL following auto-HSCT and to determine the risk factors associated with the development of AF/AFL. Patients who developed AF/AFL were compared with a group of patients who received auto-HSCT within the same time period (April 1999 to May 2005) and were within 5 years of age. Of the 516 patients who underwent auto-HSCT at the University of Nebraska Medical Center 44 (8.5%) developed AF/AFL at a median time of 4 days (range, days 1–9) following auto-HSCT. In multivariate analysis, risk factors for developing AF/AFL were older age, odds ratio and 95% CI of 1.14 (1.07–1.21), elevated serum creatinine level, 2.69 (1.00–7.22), history of previous arrhythmia, 9.33 (3.01–28.99), and history of previous mediastinal irradiation, 11.12 (1.33–92.96).

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Acknowledgements

We would like to thank the University of Nebraska Medical Center for their continued support.

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Authors and Affiliations

  1. Internal Medicine Section of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA

    J A Steuter & A Easley

  2. Internal Medicine, Medical Oncology/Hematology, Hematology/Oncology of Yankton, Yankton, SD, USA

    M L H Villanueva

  3. Internal Medicine Section Oncology/Hematology, University of Nebraska Medical Center, Omaha, NE, USA

    F R Loberiza, J O Armitage, R G Bociek, A K Ganti, J M Vose & P J Bierman

  4. VA Nebraska Western Iowa Health Care System, Omaha, NE, USA

    A K Ganti

  5. Nebraska Cancer Specialists, Omaha, NE, USA

    S R Tarantolo

Authors
  1. J A Steuter
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  2. M L H Villanueva
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  3. F R Loberiza
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  4. J O Armitage
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  5. R G Bociek
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  6. A K Ganti
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  8. J M Vose
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  9. A Easley
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  10. P J Bierman
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Correspondence to J A Steuter.

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Steuter, J., Villanueva, M., Loberiza, F. et al. Factors affecting the development of atrial fibrillation and atrial flutter (AF/AFL) following autologous hematopoietic SCT (auto-HSCT). Bone Marrow Transplant 48, 963–965 (2013). https://doi.org/10.1038/bmt.2012.253

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  • DOI: https://doi.org/10.1038/bmt.2012.253

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