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Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 48, pages 612–613 (2013)Cite this article

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Three clinical trials are being conducted in Brazil by our research group on the use of autologous, BM-derived, hematopoietic SCT (auto-BMHSCT) for the treatment of retinitis pigmentosa (RP), dry age-related macular degeneration and ischaemic retinopathy (including diabetic retinopathy with macular ischaemia). These studies are registered with ClinicalTrials.gov, numbers NCT01068561, NCT01518127 and NCT01518842, respectively.1

The pathophysiology of macular oedema associated with retinitis is still controversial, but it may possibly be due to the blood–retinal barrier breakdown. However, the mechanism by which auto-BMHSCT led to improvement of the oedema is still subject to speculation.7 The population of adult stem cells in the BM can restore the blood ocular barrier through a paracrine effect or interfere with the osmotic gradient, favouring the absorption of the oedema fluid.8, 9

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Authors and Affiliations

  1. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto,University of São Paulo, Ribeirão Preto, Brazil

    R C Siqueira, A Messias, K Messias, R S Arcieri & R Jorge

  2. Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    J C Voltarelli

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  1. R C Siqueira
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  2. A Messias
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  3. J C Voltarelli
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Correspondence to R C Siqueira.

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Siqueira, R., Messias, A., Voltarelli, J. et al. Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation. Bone Marrow Transplant 48, 612–613 (2013). https://doi.org/10.1038/bmt.2012.185

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