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Allogeneic hematopoietic stem cell donation—standardized assessment of donor outcome data: A consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT)

Abstract

The number of allogeneic hematopoietic SCTs performed globally each year continues to increase, paralleled by an increased demand for donors of therapeutic cells. Donor characteristics and collection procedures have undergone major changes during recent decades, and further changes are foreseen. Information on short- and long-term donor outcomes is of crucial importance to ensure maximal donor safety and availability. Current data, predominantly from unrelated donors, give reliable information on the frequent early events associated with donation—most of them of mild-to-moderate intensity. Information on the type and relative risk of serious adverse reactions is more limited. Moreover, only few data exist on long-term donor outcome. On the basis of this need, recommendations for a minimum data set for prospective donor follow-up were developed in a workshop with the participation of an international group of investigators actively involved in allogeneic stem cell donation under the auspices of and approved by the Worldwide Network for Blood and Marrow Transplantation. Establishment of a standardized global follow-up for both, related and unrelated, donors will enable monitoring of the short- and long-term safety profiles of hematopoietic cell donation and form a solid basis for future donor selection and counseling.

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Acknowledgements

This work was supported by the Swiss Blood Stem Cells (SBSC), generously supporting the organization of the meeting in Bern, and a grant from the Swiss National Research Foundation (406340-128111).

Author contributions: JPH, SMvW, NW, MB, HH, GNdF, AHS, MF, AG and DC attended the workshop and wrote the paper. BES, AM, JS, MDA, DW, MMH, HG, DW and YK contributed the comments and wrote the paper.

Participants of the donor outcome workshop in alphabetical order: F Audat (France Greffe de Moelle), L Ball (LUMC), M Bengtsson (Tobias Registry), L Brezinova (Czech Stem Cells Registry), E Buhrfeind (SBSC), D Confer (NMDP/CIBMTR), M Fechter (Europdonor), A Gratwohl (University Hospital Basel), H Hägglund (Karolinksa University Hospital, Huddinge/Nordic donor registry), J Halter (University Hospital Basel), R King (NMDP/CIBMTR), E Korthof (LUMC), E Lawlor (IBTS), E Marry (France Greffe de Moelle), T Mengling (DKMS), J Ng-McClelland (CW Bill Young DOD Marrow Donor Program), G Nicoloso de Faveri (SBSC), S Rajadhyasksha (Tata Memorial Hospital), A Rosenmayr (Austrian Bone Marrow Registry), M Reti (Szent Istvan and Szent Laszlo University hospital Budapest), AH Schmidt (DKMS), C Tassi (University Hospital Bologna), SM van Walraven (Europdonor, WMDA), N Worel (Medical University of Vienna), L Zahlavova (Czech Stem Cells Registry)

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Correspondence to J P Halter.

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Halter, J., van Walraven, S., Worel, N. et al. Allogeneic hematopoietic stem cell donation—standardized assessment of donor outcome data: A consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Bone Marrow Transplant 48, 220–225 (2013). https://doi.org/10.1038/bmt.2012.119

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Keywords

  • donor outcome
  • global donor follow-up
  • serious adverse reactions
  • minimal data set
  • WBMT

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