Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Recurrence of β-thalassemia major more than 20 years after HLA-identical sibling BMT treated successfully with donor lymphocyte infusion

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Thomas ED, Buckner CD, Sanders JE, Papayannopoulou T, Borgna-Pignatti C, De Stefano P et al. Marrow transplantation for thalassaemia. Lancet 1982; 2: 227–229.

    Article  CAS  PubMed  Google Scholar 

  2. Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C et al. Bone marrow transplantation in patients with thalassemia. N Engl J Med 1990; 322: 417–421.

    Article  CAS  PubMed  Google Scholar 

  3. Andreani M, Manna M, Lucarelli G, Tonucci P, Agostinelli F, Ripalti M et al. Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood 1996; 87: 3494–3499.

    CAS  PubMed  Google Scholar 

  4. Kapelushnik J, Naparstek E, Nagler A, Filon D, Oppenheim A, Amar A et al. Second transplantation using allogeneic peripheral blood stem cells in a beta-thalassaemia major patient featuring stable mixed chimaerism. Br J Haematol 1996; 94: 285–287.

    Article  PubMed  Google Scholar 

  5. Gaziev J, Sodani P, Lucarelli G, Polchi P, Marktel S, Paciaroni K et al. Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft. Bone Marrow Transplant 2008; 42: 397–404.

    Article  CAS  PubMed  Google Scholar 

  6. Kolb HJ, Mittermuller J, Clemm C, Holler E, Ledderose G, Brehm G et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990; 76: 2462–2465.

    CAS  PubMed  Google Scholar 

  7. Aker M, Kapelushnik J, Pugatsch T, Naparstek E, Ben-Neria S, Yehuda O et al. Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for beta-thalassemia major. J Pediatr Hematol Oncol 1998; 20: 145–148.

    Article  CAS  PubMed  Google Scholar 

  8. Frugnoli I, Cappelli B, Chiesa R, Biral E, Noe A, Evangelio C et al. Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia. Bone Marrow Transplant 2010; 45: 1047–1051.

    Article  CAS  PubMed  Google Scholar 

  9. Flowers ME, Leisenring W, Beach K, Riddell S, Radich JP, Higano CS et al. Granulocyte colony-stimulating factor given to donors before apheresis does not prevent aplasia in patients treated with donor leukocyte infusion for recurrent chronic myeloid leukemia after bone marrow transplantation. Biol Blood Marrow Transplant 2000; 6: 321–326.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported in part by grant CA15704 from the National Cancer Institute, and HL36444 from the National Heart, Lung, Blood Institute. YI is a recipient of the Banyu Fellowship Program from Banyu Life Science Foundation International. We thank Carina Moravec, ARNP, for assistance in the care of this patient and Anjani Kumar for assistance with medical records.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M E D Flowers.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Inamoto, Y., Yannucci, J., Storb, R. et al. Recurrence of β-thalassemia major more than 20 years after HLA-identical sibling BMT treated successfully with donor lymphocyte infusion. Bone Marrow Transplant 46, 1037–1038 (2011). https://doi.org/10.1038/bmt.2011.37

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2011.37

Search

Quick links