Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Allogeneic hematopoietic stem cell collection from a donor with end-stage renal disease

Bone Marrow Transplantation volume 47, pages 157–158 (2012)Cite this article

Collection of HSCs for the purpose of allogeneic transplantation is achieved mostly by either apheresis of peripheral blood after mobilization with G-CSF, or by direct BM aspiration.1 Potential donors are submitted to a thorough workup, including history questionnaire, physical examination and laboratory testing, as per published regulations.2 This workup aims at minimizing health risks related to the collection for the donor, and also at protecting the recipient from transmissible diseases. In the setting of unrelated donor registries, recommendations for deferral according to precise medical conditions have been issued by the World Marrow Donor Association.3 The same rigorous precautions should be applied to family donors, and an alternative source of HSCs is usually recommended if the donor suffers from a chronic medical condition that significantly increases collection-related health risks. However, a readily accessible alternative donor is not always immediately available. Related donors will sometimes request to proceed with HSC collection despite a heightened risk for themselves because of underlying medical conditions. Physicians need to consider these donor preferences.

We report the case of a 58-year-old male with end-stage renal disease (ESRD) who committed to donate HSCs to his HLA-identical brother referred for secondary acute myeloid leukemia in remission and requiring urgent transplantation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Copelan EA . Hematopoietic stem-cell transplantation. N Engl J Med 2006; 354: 1813–1826.

    Article  CAS  PubMed  Google Scholar 

  2. FACT-JACIE Cellular Therapy Accreditation Manual 4th edn, October 2008, available at http://www.jacie.org/collage/images/potter/tempFiles/potterTmpFile_uuid_54633/FACT-JACIE%2B4th%2Bed%2BStandards.pdf.

  3. Sacchi N, Costeas P, Hartwell L, Hurley CK, Raffoux C, Rosenmayr A et al. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant 2008; 42: 9–14.

    Article  CAS  PubMed  Google Scholar 

  4. Bird JM, Fuge R, Sirohi B, Apperley JF, Hunter A, Snowden J et al. The clinical outcome and toxicity of high-dose chemotherapy and autologous stem cell transplantation in patients with myeloma or amyloid and severe renal impairment: a British Society of Blood and Marrow Transplantation study. Br J Haematol 2006; 134: 385–390.

    Article  CAS  PubMed  Google Scholar 

  5. Akizawa T, Shishido K, Koshikawa S . The effects and pharmacokinetics of rhG-CSF in patients with chronic renal failure. Artif Organs 1995; 19: 1251–1257.

    Article  CAS  PubMed  Google Scholar 

  6. Product monograph for Neupogen, Amgen Canada Inc. Last revised 18 August 2009. Accessed via http://www.amgen.ca/Neupogen.pdf.

Download references

Author information

Authors and Affiliations

  1. Division of Hematology and Medical Oncology, Hematopoietic Cell Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, Quebec, Canada

    I Ahmad, T Kiss, S Lachance, J Roy & S Cohen

Authors
  1. I Ahmad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T Kiss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Lachance
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I Ahmad.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ahmad, I., Kiss, T., Lachance, S. et al. Allogeneic hematopoietic stem cell collection from a donor with end-stage renal disease. Bone Marrow Transplant 47, 157–158 (2012). https://doi.org/10.1038/bmt.2011.31

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2011.31

Search

Advanced search

Quick links