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Microbial Issues

The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study

Bone Marrow Transplantation volume 47, pages 88–94 (2012)Cite this article

Abstract

The clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.

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Acknowledgements

We thank the data managers and transplant physicians at participating centres for providing data.

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Authors and Affiliations

  1. Bristol Adult Bone Marrow Transplant Unit, University Hospitals Bristol, Bristol, UK

    R E Protheroe & D I Marks

  2. British Society of Blood and Marrow Transplantation Data Registry, London, UK

    K E Kirkland

  3. Clinical Trials Committee Statistician, British Society of Blood and Marrow Transplantation, London, UK

    R M Pearce

  4. University College Hospital, London, UK

    K Kaminaris

  5. Department of Haematology, Christie Hospital, Manchester, UK

    A Bloor

  6. Bone Marrow Transplant Unit, Royal Marsden Hospital, London, UK

    M N Potter

  7. Centre for Clinical Haematology, University Hospital, Birmingham, UK

    S Nagra

  8. St James’ Hospital, Leeds, UK

    M H Gilleece & G Cook

  9. Bone Marrow Transplant Unit, Glasgow Royal Infirmary, Glasgow, UK

    I G McQuaker

  10. Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

    G Jackson

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  1. R E Protheroe
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Correspondence to D I Marks.

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Protheroe, R., Kirkland, K., Pearce, R. et al. The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study. Bone Marrow Transplant 47, 88–94 (2012). https://doi.org/10.1038/bmt.2011.12

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  • DOI: https://doi.org/10.1038/bmt.2011.12

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