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Possible involvement of G-CSF in IgA nephropathy developing in an allogeneic peripheral blood SCT donor

Bone Marrow Transplantation volume 45, pages 1477–1478 (2010)Cite this article

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IgA nephropathy (IgAN) is the most common form of glomerulonephritis and a principal cause of end-stage renal disease (ESRD) throughout the world.1 Selectins are cell-to-cell adhesion molecules involved in the leukocyte–endothelial cell interaction leading to leukocytic infiltration into tissue.2 Leukocytic infiltration into the glomerulus and renal interstitium appears to be critical for the pathogenesis of IgAN.

G-CSF is widely used to induce neutrophil production after myelosuppressive treatment and to mobilize BM hematopoietic progenitors that are provided for hematopoietic stem cell transplantation (HSCT) recipients. Although G-CSF is normally well-tolerated, it has been associated with rare but serious toxicities including splenic rupture, allergic reactions, flares of underlying autoimmune disorders and vascular complications,3, 4 as previously reviewed by Tigue et al.,5 as well as hematological malignancies.6

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Authors and Affiliations

  1. Department of Pediatrics, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan

    Y Funakoshi, Y Nakashima, K Nakashima, M Okada & H Moriuchi

  2. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    A Nazneen, Y Nakashima & T Taguchi

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  1. Y Funakoshi
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  2. A Nazneen
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  3. Y Nakashima
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  6. T Taguchi
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  7. H Moriuchi
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Correspondence to H Moriuchi.

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Funakoshi, Y., Nazneen, A., Nakashima, Y. et al. Possible involvement of G-CSF in IgA nephropathy developing in an allogeneic peripheral blood SCT donor. Bone Marrow Transplant 45, 1477–1478 (2010). https://doi.org/10.1038/bmt.2010.4

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