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Inadvertent transplantation of haematopoietic stem cells carrying constitutional Robertsonian translocation from an apparently normal donor to an AML patient: a case report

Bone Marrow Transplantation volume 46, pages 1278–1279 (2011)Cite this article

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Robertsonian translocations (RTs) are relatively common constitutional cytogenetic abnormalities involving the acrocentric chromosomes 13, 14, 15, 21 and 22.1 In subjects in whom RTs occur, there are no overt clinical consequences. RTs can also rarely be discovered in tumour cells obtained from some haematological malignant cases. In such cases they are acquired cytogenetic aberrations and almost always result in a trisomic karyotype that could contribute to clonal evolution of the underlying neoplastic disease.2, 3, 4 We report a case of transplantation of haematopoietic stem cells (HSCs) bearing RTs from an apparently healthy BM donor to a recipient with AML.

A 23-year-old man was referred in February 2006 because of AML. The karyotype of BM leukaemic cells was 47,XY,+4. The patient underwent induction chemotherapy and CR was obtained. Cytogenetic analysis performed on BM cells in the first CR showed a normal karyotype.

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  1. Bone Marrow Transplantation Unit, Ospedale Ferrarotto, Azienda Ospedaliera Policlinico-Vittorio Emanuele, Catania, Italy

    C Consoli, S Leotta, L Tambè, A L Di Marco, G Avola, M G Camuglia, S Di Mercurio, M Poidomani & G Milone

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  1. C Consoli
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  2. S Leotta
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  3. L Tambè
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  4. A L Di Marco
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  5. G Avola
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  6. M G Camuglia
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  7. S Di Mercurio
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  8. M Poidomani
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  9. G Milone
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Correspondence to G Milone.

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Consoli, C., Leotta, S., Tambè, L. et al. Inadvertent transplantation of haematopoietic stem cells carrying constitutional Robertsonian translocation from an apparently normal donor to an AML patient: a case report. Bone Marrow Transplant 46, 1278–1279 (2011). https://doi.org/10.1038/bmt.2010.296

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