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Donor-cell MDS in a 12-year-old girl 3 years after allogeneic hematopoietic SCT for MDS, both with a t(3;3)(q21;q26) cytogenetic aberration

Bone Marrow Transplantation volume 46, pages 908–910 (2011)Cite this article

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Secondary malignancies after SCT are a known late complication and generally fall into three general categories: solid tumors, hematologic malignancies (primarily therapy-related myelodysplastic syndrome (MDS) and AML) and post-transplant lymphoproliferative disorders.1 The post-transplant acute leukemias and MDS generally arise from the recipient's cells. Rarely, secondary leukemias, and even less frequently MDS, are derived from donor cells.

We describe the case of a girl with MDS who received an allo-SCT from an HLA-identical sibling and subsequently developed MDS derived from donor stem cells. This donor cell-derived MDS had the same cytogenetic abnormality as the original clone from the recipient, suggesting familial disease. Nevertheless, the donor had normal cytogenetics and remained disease-free.

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References

  1. Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL . New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 2003; 21: 1352–1358.

    Article  PubMed  Google Scholar 

  2. de Weger RA, Tilanus MG, Scheidel KC, van den Tweel JG, Verdonck LF . Monitoring of residual disease and guided donor leucocyte infusion after allogeneic bone marrow transplantation by chimaerism analysis with short tandem repeats. Br J Haematol 2000; 110: 647–653.

    Article  CAS  PubMed  Google Scholar 

  3. Grigg AP, Gascoyne RD, Phillips GL, Horsman DE . Clinical, haematological and cytogenetic features in 24 patients with structural rearrangements of the Q arm of chromosome 3. Br J Haematol 1993; 83: 158–165.

    Article  CAS  PubMed  Google Scholar 

  4. Jotterand BM, Parlier V, Muhlematter D, Grob JP, Beris P . Three new cases of chromosome 3 rearrangement in bands q21 and q26 with abnormal thrombopoiesis bring further evidence to the existence of a 3q21q26 syndrome. Cancer Genet Cytogenet 1992; 59: 138–160.

    Article  Google Scholar 

  5. Reichard KK, Zhang QY, Sanchez L, Hozier J, Viswanatha D, Foucar K . Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. Am J Hematol 2006; 81: 178–185.

    Article  PubMed  Google Scholar 

  6. Hertenstein B, Hambach L, Bacigalupo A, Schmitz N, McCann S, Slavin S et al. Development of leukemia in donor cells after allogeneic stem cell transplantation—a survey of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2005; 90: 969–975.

    PubMed  Google Scholar 

  7. Ataergin S, Arpaci F, Cetin T, Guran S, Yakicier C, Beyzadeoglu M et al. Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia. Am J Hematol 2006; 81: 370–373.

    Article  PubMed  Google Scholar 

  8. Brunstein CG, Hirsch BA, Hammerschmidt D, McGlennen RC, Nguyen PL, Verfaillie CM . Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplant 2002; 29: 999–1003.

    Article  CAS  PubMed  Google Scholar 

  9. Komeno Y, Kanda Y, Kandabashi K, Kawazu M, Goyama S, Takeshita M et al. Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin. Am J Hematol 2003; 72: 220–222.

    Article  PubMed  Google Scholar 

  10. Komrokji R, Ifthikharuddin JJ, Felgar RE, Abboud CN, Wedow LA, Connaughton A et al. Donor cell myelodysplastic syndrome after allogeneic stem cell transplantation responding to donor lymphocyte infusion: case report and literature review. Am J Hematol 2004; 76: 389–394.

    Article  PubMed  Google Scholar 

  11. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010; 464: 852–857.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We especially like to thank Joyce H van Loon for her technical assistance in all the chimerism analyses over the years.

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Authors and Affiliations

  1. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

    R J Leguit

  2. Department of Pediatric Hematology—Oncology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

    H van den Berg

  3. Department of Pediatric Oncology, Emma Children Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    A Buijs

  4. Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    C Mellink

  5. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

    M Bierings

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  1. R J Leguit
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  2. H van den Berg
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Correspondence to R J Leguit.

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The authors declare no conflict of interest.

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Leguit, R., van den Berg, H., Buijs, A. et al. Donor-cell MDS in a 12-year-old girl 3 years after allogeneic hematopoietic SCT for MDS, both with a t(3;3)(q21;q26) cytogenetic aberration. Bone Marrow Transplant 46, 908–910 (2011). https://doi.org/10.1038/bmt.2010.214

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