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Immunomodulation by IFN-γ in patients with resistant infections and accompanying bronchiolitis obliterans following allo-SCT

Bone Marrow Transplantation volume 46, pages 756–758 (2011)Cite this article

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Fungal infections, mainly caused by Aspergillus species1 as well as severe GVHD are the most serious long-term complications after allo-SCT. They frequently occur simultaneously due to the profound immunodeficiency in GVHD or to pulmonary involvement such as in patients suffering from bronchiolitis obliterans (BO), a severe manifestation of chronic pulmonary GVHD. Therefore, new treatment approaches involving immunomodulation are urgently needed.

Here, we report efficacy and tolerability of a supportive treatment option with IFN-γ in patients with relapsing infections after allo-SCT and discuss a potential beneficial effect in concomitant BO.

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Authors and Affiliations

  1. Department of Hematology and Clinical Oncology, University of Regensburg, Regensburg, Germany

    J Ammer, J Hahn, D Wolff, B Holler, K Landfried, A Hautmann, M Grube, R Andreesen & E Holler

  2. Department of Radiology, University of Regensburg, Regensburg, Germany

    O I Hamer

  3. Department of Internal Medicine II, University of Regensburg, Regensburg, Germany

    Ch Schulz

  4. LSU Health Sciences Center, Shreveport, LA, USA

    G Hildebrandt

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  1. J Ammer
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  2. J Hahn
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  3. D Wolff
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  4. B Holler
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  5. K Landfried
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  6. A Hautmann
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  7. O I Hamer
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  8. Ch Schulz
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  9. G Hildebrandt
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  10. M Grube
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  11. R Andreesen
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  12. E Holler
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Correspondence to E Holler.

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The authors declare no conflict of interest.

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Ammer, J., Hahn, J., Wolff, D. et al. Immunomodulation by IFN-γ in patients with resistant infections and accompanying bronchiolitis obliterans following allo-SCT. Bone Marrow Transplant 46, 756–758 (2011). https://doi.org/10.1038/bmt.2010.172

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