Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Histocompatibility and Donor Selection

World Marrow Donor Association framework for the implementation of HLA matching programs in hematopoietic stem cell donor registries and cord blood banks

Abstract

A major goal of the World Marrow Donor Association (WMDA) is to foster international transplants of hematopoietic stem cells through the establishment of guidelines and recommendations in this field. In this tradition, this study defines a comprehensive framework for HLA matching programs, which use intricate algorithms to rapidly select potential donors for a patient from a database and to present these donors in a prioritized list. Starting with the comparison of single HLA markers of the donor and the patient possibly obtained using different testing methodologies at different resolutions, the more complex matching of loci and phenotypes is inductively built up. The consensus of this international collaborative group describes the state of the art in the field and points out many important design options compatible with the best practice. This should help existing registries to review and validate the most critical part of their IT systems and newly created donor registries around the world to tackle one of their real challenges.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Robinson J, Waller MJ, Fail SJ, McWilliam H, Lopez R, Parham P et al. The IMGT/HLA database. Nucleic Acids Res 2009; 37: D1013–D1017.

    CAS  Article  PubMed  Google Scholar 

  2. Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010; 75: 291–455.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. Bochtler W, Maiers M, Oudshoorn M, Marsh SGE, Raffoux C, Mueller C et al. World Marrow Donor Association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks. Bone Marrow Transplant 2007; 39: 737–741.

    CAS  Article  PubMed  Google Scholar 

  4. Cano P, Klitz W, Mack SJ, Maiers M, Marsh SGE, Noreen H et al. Common and well-documented HLA alleles: report of the Ad-Hoc Committee of the American Society for Histocompatiblity and Immunogenetics. Hum Immunol 2007; 68: 392–417.

    CAS  Article  PubMed  Google Scholar 

  5. Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004; 104: 1923–1930.

    CAS  Article  PubMed  Google Scholar 

  6. Petersdorf EW, Hansen JA, Martin PJ, Woolfrey A, Malkki M, Gooley T et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med 2001; 345: 1794–1800.

    CAS  Article  PubMed  Google Scholar 

  7. Wade JA, Hurley CK, Takemoto SK, Thompson J, Davies SM, Fuller TC et al. HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation. Blood 2007; 109: 4064–4070.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007; 110: 4576–4587.

    CAS  Article  PubMed  Google Scholar 

  9. Heemskerk MBA, Cornelissen JJ, Roelen DL, van Rood JJ, Claas FHJ, Doxiadis IIN et al. Highly diverged MHC class I mismatches are acceptable for haematopoietic stem cell transplantation. Bone Marrow Transplant 2007; 40: 193–200.

    CAS  Article  PubMed  Google Scholar 

  10. Holdsworth R, Hurley CK, Marsh SGE, Lau M, Noreen HJ, Kempenich JH et al. The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens. Tissue Antigens 2009; 63: 95–170.

    Article  Google Scholar 

  11. Hurley CK, Setterholm M, Lau M, Pollack MS, Noreen H, Howard A et al. Hematopoietic stem cell donor registry strategies for assigning search determinants and matching relationships. Bone Marrow Transplant 2004; 33: 443–450.

    CAS  Article  PubMed  Google Scholar 

  12. Maiers M, Bakker JNA, Bochtler W, Eberhard H-P, Marsh SGE, Müller C et al. Information technology and the role of WMDA in promoting standards for international exchange of hematopoietic stem cell donors and products. Bone Marrow Transplant 2010; 45: 839–842.

    CAS  Article  PubMed  Google Scholar 

  13. Oudshoorn M, van Leeuwen A, vd Zanden HG, van Rood JJ . Bone Marrow Donors Worldwide: a successful exercise in international cooperation. Bone Marrow Transplant 1994; 14: 3–8.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This has been a project of the Information Technology Working Group of the WMDA. Working group members and the WMDA Board have provided valuable input to this paper.

Author information

Authors and Affiliations

Authors

Consortia

Corresponding author

Correspondence to W Bochtler.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on Bone Marrow Transplantation website

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bochtler, W., Maiers, M., Bakker, J. et al. World Marrow Donor Association framework for the implementation of HLA matching programs in hematopoietic stem cell donor registries and cord blood banks. Bone Marrow Transplant 46, 338–343 (2011). https://doi.org/10.1038/bmt.2010.132

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2010.132

Keywords

  • HLA
  • donor selection
  • matching program
  • framework
  • hematopoietic SCT
  • cord blood banks

Further reading

Search

Quick links