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Palifermin, a recombinant human keratinocyte growth factor, triggers reactivation of anogenital human papillomavirus infection in a HIV-positive patient with diffuse large cell B-cell non-Hodgkin lymphoma

Bone Marrow Transplantation volume 44, pages 823–824 (2009)Cite this article

Anogenital human papillomavirus (HPV) is a common sexually transmitted infection and is associated with cutaneous manifestations varying from inapparent infections to genital warts, condylomata accuminata and different types of anogenital cancers such as anal, vulva or cervix carcinoma. HPVs are strictly epitheliotropic, preferentially targeting squamous epithelial cells. There are at least 90 genotypes including HPV6 and HPV11, which are found in 70–100% of the condylomata accuminata. The latter ones are referred to as benign or ‘low-risk HPV types’, whereas other genotypes, particularly HPV16 and HPV18, are termed ‘high-risk HPV types’ because of their oncogenic potential.1

The recombinant human keratinocyte growth factor (KGF) Palifermin is a member of the fibroblast growth factor family and promotes proliferation and differentiation of several epithelial tissues such as transitional urothelial cells, hepatocytes, type II pneumocytes, gastrointestinal epithelial cells and in particular epidermal cells via binding to the human KGF receptor.2, 3 Palifermin is currently used for prophylaxis of oral mucositis following high-dose chemo- and/or radiotherapy and autologous blood SCT.4

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Acknowledgements

GK received lecture fees from Amgen.

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Authors and Affiliations

  1. Department for Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany

    T Schroeder, F Zohren, C Saure, G Kobbe & R Haas

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  1. T Schroeder
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  2. F Zohren
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  3. C Saure
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  4. G Kobbe
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Correspondence to T Schroeder.

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Schroeder, T., Zohren, F., Saure, C. et al. Palifermin, a recombinant human keratinocyte growth factor, triggers reactivation of anogenital human papillomavirus infection in a HIV-positive patient with diffuse large cell B-cell non-Hodgkin lymphoma. Bone Marrow Transplant 44, 823–824 (2009). https://doi.org/10.1038/bmt.2009.81

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