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Allografting

Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

Bone Marrow Transplantation volume 44, pages 589–594 (2009)Cite this article

Abstract

The aim of this multicenter retrospective analysis was to carry out a survey of overall outcomes after allo-hematopoietic SCT of AML patients harboring trisomy 8 (+8) as the sole chromosomal abnormality or associated with other abnormalities. We have identified 182 de novo AML patients who underwent allo-hematopoietic SCT between 1990 and 2007 exhibiting isolated +8 (n=136) or +8 (n=46) associated with other favorable (n=8), intermediate (n=30), high-risk (n=7) or unknown (n=1) cytogenetic abnormalities reported to the European Group of Blood and Marrow Transplantation (EBMT). With a median follow-up of 48 months, 5-year non-relapse mortality, relapse rate, leukemia-free survival and OS were 25, 30, 45 and 47%, respectively. In a multivariate analysis, leukemia-free survival rate was improved when patients were female and transplanted in CR with an HLA-identical sibling donor. Five-year leukemia-free survival was 41, 88, 57 and 21% in patients bearing isolated +8 or +8 and other cytogenetic abnormalities of good, intermediate or poor-risk, respectively. Our retrospective data show that allo-hematopoietic SCT is an effective treatment for AML patients harboring +8. The accompanying cytogenetic abnormality to +8 seems to influence outcomes of these patients.

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Acknowledgements

P Chevallier conceived and designed the study, analyzed the data, recruited the patients, provided clinical care, performed bibliographic search and wrote the paper. M Mohty and V Rocha recruited patients, provided clinical care, analyzed the data and performed bibliographic search, helped with the statistical analyses and in writing the paper. M Labopin performed data management, collection and statistical analyses. A Nagler, P Ljungman, L Verdonck, T Ruutu, A Zander, J Finke, G Socie, C Cordonnier and JL Harousseau recruited the patients, provided clinical care and commented on the paper. All the above authors approved the paper for publication purposes.

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Authors and Affiliations

  1. Haematology Department, Centre Hospitalier Universitaire (CHU) Hôtel-Dieu, Nantes, France

    P Chevallier, J-L Harousseau & M Mohty

  2. ALWP, EBMT-Paris Office, Hôpital Saint Antoine AP-HP, Université Pierre et Marie Curie Paris 6, Paris, France

    M Labopin & V Rocha

  3. Department of Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel

    A Nagler

  4. Department of Haematology, Karolinska University Hospital, Huddinge, Sweden

    P Ljungman

  5. Department of Haematology, University Medical Centre, Utrecht, Netherlands

    L F Verdonck

  6. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

    L Volin

  7. Bone Marrow Transplantation centre, University Hospital Eppendorf, Hambourg, Germany

    A R Zander

  8. Department of Medicine-Haematology, University of Freiburg, Freiburg, Germany

    J Finke

  9. Department of Haematology-BMT, Hopital Saint-Louis, Paris, France

    G Socie

  10. Department of Haematology, Henri Mondor Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) and Paris 12 University, Créteil, France

    C Cordonnier

  11. Department of Haematology, BMT, Hopital Saint-Louis, Paris, France

    V Rocha

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  1. P Chevallier
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  2. M Labopin
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  7. A R Zander
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  8. J Finke
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  9. G Socie
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  10. C Cordonnier
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  11. J-L Harousseau
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on behalf of the Acute Leukemia Working Party of the EBMT

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Correspondence to P Chevallier.

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Chevallier, P., Labopin, M., Nagler, A. et al. Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT. Bone Marrow Transplant 44, 589–594 (2009). https://doi.org/10.1038/bmt.2009.68

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