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Pathological evidence of Wolman's disease following hematopoietic stem cell transplantation despite correction of lysosomal acid lipase activity

Bone Marrow Transplantation volume 44, pages 449–450 (2009)Cite this article

Recently, Tolar et al.1 described four cases of Wolman's disease treated with SCT. In this report, a relatively high mortality rate (2/4) was noted, with the deaths attributed to sinusoidal obstruction syndrome (SOS), multi-organ failure and sepsis in the first case, and hepatic failure and sepsis in the second case.

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Authors and Affiliations

  1. Division of Pediatric Stem Cell Transplantation, Department of Pediatrics, Stanford University, Palo Alto, CA, USA

    M M Gramatges, K Weinberg & R Agarwal

  2. Division of Pediatric Blood and Marrow Transplant, Department of Pediatrics, University of California, San Francisco, CA, USA

    C C Dvorak

  3. Department of Pathology, Stanford University, Palo Alto, CA, USA

    D P Regula

  4. Department of Genetics, Stanford University, Palo Alto, CA, USA

    G M Enns

Authors
  1. M M Gramatges
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  2. C C Dvorak
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  3. D P Regula
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  5. K Weinberg
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  6. R Agarwal
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Correspondence to R Agarwal.

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Gramatges, M., Dvorak, C., Regula, D. et al. Pathological evidence of Wolman's disease following hematopoietic stem cell transplantation despite correction of lysosomal acid lipase activity. Bone Marrow Transplant 44, 449–450 (2009). https://doi.org/10.1038/bmt.2009.57

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