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T-cell post-transplant lymphoproliferative disorder in a patient with chronic idiopathic myelofibrosis following allogeneic PBSC transplantation

Bone Marrow Transplantation volume 45, pages 1372–1374 (2010)Cite this article

Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication after solid organ and hematopoietic SCTs (HSCTs). The majority are of B-cell origin and EBV related.1 Most of the T-cell PTLD cases have been described as occurring after solid organ transplantations;2 T-cell PTLD cases following HSCT are exceedingly rare. There are only three reported cases of T-cell PTLD following allogeneic HSCT3 and four cases following autologous HSCT.4, 5, 6, 7 Here we report a case of T-cell PTLD after allogeneic-PBSC transplantation (allo-PBSCT) in a patient with chronic idiopathic myelofibrosis (CIMF).

To our knowledge, there have been only four cases of T-cell PTLD following allo-SCT, including our case (Table 1). Time to T-cell PTLD diagnosis ranges from 2 to 43 months after a transplant. Although the type of PTLD was not consistent, ranging from precursor to peripheral T-cell neoplasms, none of them were associated with EBV infection. Our case was negative for EBV, and the type was peripheral T-cell lymphoma-unspecified.

Table 1 T-cell post-transplant lymphoproliferative disorder after allogeneic stem cell transplantation
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Figure 1

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Authors and Affiliations

  1. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    A Nishida, H Yamamoto, M Karasawa, D Kato, N Uchida, A Wake & S Taniguchi

  2. Department of Pathology, Toranomon Hospital, Tokyo, Japan

    Y Ohta

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  1. A Nishida
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  2. H Yamamoto
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  3. Y Ohta
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  4. M Karasawa
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  5. D Kato
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  7. A Wake
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  8. S Taniguchi
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Correspondence to H Yamamoto.

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Nishida, A., Yamamoto, H., Ohta, Y. et al. T-cell post-transplant lymphoproliferative disorder in a patient with chronic idiopathic myelofibrosis following allogeneic PBSC transplantation. Bone Marrow Transplant 45, 1372–1374 (2010). https://doi.org/10.1038/bmt.2009.347

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