Abstract
We analyzed all patients undergoing allogeneic stem cell transplantation (ASCT) and transferred to the intensive care unit (ICU) from January 1995 to December 2005. During this period, 661 patients underwent ASCT at our center. A total of 91 patients were admitted to the ICU. Median time from ASCT to ICU admission was 69 days (−24 to 1572) and median stay at the ICU was 4 (1–60) days. The survival after transfer to the ICU at day 100 and at 1 year was 22 and 16%, respectively. Median Sequential Organ Failure Assessment (SOFA) score was 10 (1–17). Patients with SOFA score <8 (n=18) had a 44% survival compared with 17% with SOFA score 8–11 (n=30) and no survival with SOFA score >11 (n=20) (P=0.0002). None of the 14 retransplanted patients survived compared with 31% among patients after first ASCT (P=0.006). Patients receiving TBI had a lower survival compared with patients treated with chemotherapy only (14 vs 45%, P=0.02). Patients needing vasopressor support had a worse survival, 15 vs 41%, compared with patients without vasopressor treatment (P=0.01). In multivariate analysis of death, SOFA score was the only significant factor (P<0.001). In conclusion, SOFA score predicted prognosis in ASCT patients treated at the ICU.
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References
Naeem N, Reed MD, Creger RJ, Youngner SJ, Lazarus HM . Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter? Bone Marrow Transplant 2006; 37: 119–133.
Afessa B, Tefferi A, Hoagland HC, Letendre L, Peters SG . Outcome of recipients of bone marrow transplants who require intensive-care unit support. Mayo Clin Proc 1992; 67: 117–122.
Diaz MA, Vicent MG, Prudencio M, Rodriguez F, Marin C, Serrano A et al. Predicting factors for admission to an intensive care unit and clinical outcome in pediatric patients receiving hematopoietic stem cell transplantation. Haematologica 2002; 87: 292–298.
Martin PL . To stop or not to stop: how much support should be provided to mechanically ventilated pediatric bone marrow and stem cell transplant patients? Respir Care Clin N Am 2006; 12: 403–419.
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301–1308.
Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest 2006; 130: 1579–1595.
Baron F, Storb R . Allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning as treatment for hematologic malignancies and inherited blood disorders. Mol Ther 2006; 13: 26–41.
Forslow U, Mattsson J, Ringden O, Klominek J, Remberger M . Decreasing mortality rate in early pneumonia following hematopoietic stem cell transplantation. Scand J Infect Dis 2006; 38: 970–976.
Hebart H, Einsele H . Specific infectious complications after stem cell transplantation. Support Care Cancer 2004; 12: 80–85.
Jackson SR, Tweeddale MG, Barnett MJ, Spinelli JJ, Sutherland HJ, Reece DE et al. Admission of bone marrow transplant recipients to the intensive care unit: outcome, survival and prognostic factors. Bone Marrow Transplant 1998; 21: 697–704.
Moreno R, Vincent JL, Matos R, Mendonca A, Cantraine F, Thijs L et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis Related Problems of the ESICM. Intensive Care Med 1999; 25: 686–696.
Ulvik A, Kvale R, Wentzel-Larsen T, Flaatten H . Multiple organ failure after trauma affects even long-term survival and functional status. Crit Care 2007; 11: R95.
Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on ‘sepsis-related problems’ of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26: 1793–1800.
Uzunel M, Remberger M, Sairafi D, Hassan Z, Mattsson J, Omazic B et al. Unrelated versus related allogeneic stem cell transplantation after reduced intensity conditioning. Transplantation 2006; 82: 913–919.
Remberger M, Svahn BM, Mattsson J, Ringden O . Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation. Transplantation 2004; 78: 122–127.
Ringden O, Horowitz MM, Sondel P, Gale RP, Biggs JC, Champlin RE et al. Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia? Blood 1993; 81: 1094–1101.
Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med 1986; 314: 729–735.
Hentschke P, Remberger M, Mattsson J, Barkholt L, Aschan J, Ljungman P et al. Clinical tolerance after allogeneic hematopoietic stem cell transplantation: a study of influencing factors. Transplantation 2002; 73: 930–936.
Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707–710.
Faber-Langendoen K, Caplan AL, McGlave PB . Survival of adult bone marrow transplant patients receiving mechanical ventilation: a case for restricted use. Bone Marrow Transplant 1993; 12: 501–507.
Schuster DP, Marion JM . Precedents for meaningful recovery during treatment in a medical intensive care unit. Outcome in patients with hematologic malignancy. Am J Med 1983; 75: 402–408.
Tremblay LN, Hyland RH, Schouten BD, Hanly PJ . Survival of acute myelogenous leukemia patients requiring intubation/ventilatory support. Clin Invest Med 1995; 18: 19–24.
Kew AK, Couban S, Patrick W, Thompson K, White D . Outcome of hematopoietic stem cell transplant recipients admitted to the intensive care unit. Biol Blood Marrow Transplant 2006; 12: 301–305.
Lim Z, Pagliuca A, Simpson S, Cottam S, Ervine M, Ho AY et al. Outcomes of patients with haematological malignancies admitted to intensive care unit. A comparative review of allogeneic haematopoietic stem cell transplantation data. Br J Haematol 2007; 136: 448–450.
Ringden O, Le Blanc K . Allogeneic hematopoietic stem cell transplantation: state of the art and new perspectives. APMIS 2005; 113: 813–830.
Ringden O, Remberger M, Ruutu T, Nikoskelainen J, Volin L, Vindelov L et al. Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. Blood 1999; 93: 2196–2201.
Inoue T, Ikeda H, Yamazaki H, Tang JT, Song C, Teshima T et al. Role of total body irradiation as based on the comparison of preparation regimens for allogeneic bone marrow transplantation for acute leukemia in first complete remission. Strahlenther Onkol 1993; 169: 250–255.
Morgan M, Dodds A, Atkinson K, Szer J, Downs K, Biggs J . The toxicity of busulphan and cyclophosphamide as the preparative regimen for bone marrow transplantation. Br J Haematol 1991; 77: 529–534.
Trinkaus MA, Lapinsky SE, Crump M, Keating A, Reece DE, Chen C et al. Predictors of mortality in patients undergoing autologous hematopoietic cell transplantation admitted to the intensive care unit. Bone Marrow Transplant 2009; 43: 411–415.
Michallet M, Tanguy ML, Socie G, Thiebaut A, Belhabri A, Milpied N et al. Second allogeneic haematopoietic stem cell transplantation in relapsed acute and chronic leukaemias for patients who underwent a first allogeneic bone marrow transplantation: a survey of the Societe Francaise de Greffe de moelle (SFGM). Br J Haematol 2000; 108: 400–407.
Larsson K, Gamrin L, Wernerman J . Mortalitet under IVA-vård. In: SFAI-Veckan: Norrköping, 2005.
Silfvast T, Pettila V, Ihalainen A, Elonen E . Multiple organ failure and outcome of critically ill patients with haematological malignancy. Acta Anaesthesiol Scand 2003; 47: 301–306.
Jones AE, Focht A, Horton JM, Kline JA . Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest 2007; 132: 425–432.
Rivers E . The outcome of patients presenting to the emergency department with severe sepsis or septic shock. Crit Care 2006; 10: 154.
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We thank the staff at the Centre for Allogeneic Stem Cell Transplantation and at the Department for Anesthesiology and Intensive Care Medicine for competent and compassionate care of the patients.
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Gilli, K., Remberger, M., Hjelmqvist, H. et al. Sequential Organ Failure Assessment predicts the outcome of SCT recipients admitted to intensive care unit. Bone Marrow Transplant 45, 682–688 (2010). https://doi.org/10.1038/bmt.2009.220
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DOI: https://doi.org/10.1038/bmt.2009.220
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