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Herpes simplex virus encephalitis after allogeneic transplantation: an instructive case

Bone Marrow Transplantation volume 45, pages 776–778 (2010)Cite this article

Immune reconstitution is often impaired for months to years in patients undergoing allogeneic hematopoietic cell transplantation (HCT) and predisposes them to a wide variety of bacterial, viral and fungal infections.

Primary herpes simplex virus (HSV) types 1 and 2 infections in immune-competent hosts most often lead to long-term latent infections and can be associated with recurrent reactivations. HSV-1 is responsible for the majority of nonendemic cases of viral encephalitis, accounts for 10–20% of the 20 000 annual viral encephalitis cases in the United States and is the most common cause of fatal sporadic encephalitis.1

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Authors and Affiliations

  1. Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA

    R Romee, C G Brunstein, D J Weisdorf & N S Majhail

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  1. R Romee
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  2. C G Brunstein
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  3. D J Weisdorf
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  4. N S Majhail
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Correspondence to N S Majhail.

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Romee, R., Brunstein, C., Weisdorf, D. et al. Herpes simplex virus encephalitis after allogeneic transplantation: an instructive case. Bone Marrow Transplant 45, 776–778 (2010). https://doi.org/10.1038/bmt.2009.208

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