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Post-transplant Events

Invasive Aspergillus infections in allo-SCT recipients: environmental sampling, nasal and oral colonization and galactomannan testing

Bone Marrow Transplantation volume 45, pages 333–338 (2010)Cite this article

Abstract

A study was performed to investigate the air quality of a haematopoietic SCT ward, colonization of the upper airways with Aspergillus spp. and the role of galactomannan (GM) ELISA testing in serum in the diagnosis of invasive aspergillosis (IA). In 102 allo-SCT recipients, two cases of IA (one proven and one probable) were seen. Of 2071 serum samples, 12 were positive, two in a patient with proven IA and 10 in patients without IA. Of the 2059 negative samples, 22 were taken from the patient with probable IA. Of the 245 environmental samples, 20 (8.2%) were positive for filamentous fungi. Aspergillus fumigatus was seen in 14 samples. A total of 657 oral and nasal swabs were taken. Seven nasal samples and one oral sample were positive for Aspergillus species (A. fumigatus 4, A. niger 4) in four patients, one of whom had probable IA. In summary, most environmental samples were negative, colonization of the oral and nasal cavities was rare and IA was diagnosed in only 2% of patients. The GM ELISA test remained negative in one of two patients with IA and does not seem useful in a population of patients with a low incidence of IA.

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Acknowledgements

We thank research nurses Anne Gesterberg, Suvi Mantere and Marja Pekkanen for their contribution to this study. This study was supported in part by Helsinki University Central Hospital Research Funds, Blood Disease Research Foundation, Swedish Orphan AB and Gilead Sciences, Europe.

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Authors and Affiliations

  1. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

    A Nihtinen, V-J Anttila, T Ruutu, E Juvonen & L Volin

  2. Department of Bacteriology and Immunology, Haartman Institute, Helsinki, Finland

    M Richardson & T Meri

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  1. A Nihtinen
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  2. V-J Anttila
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  3. M Richardson
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  4. T Ruutu
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  7. L Volin
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Correspondence to A Nihtinen.

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Nihtinen, A., Anttila, VJ., Richardson, M. et al. Invasive Aspergillus infections in allo-SCT recipients: environmental sampling, nasal and oral colonization and galactomannan testing. Bone Marrow Transplant 45, 333–338 (2010). https://doi.org/10.1038/bmt.2009.169

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