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Autografting

Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group

Bone Marrow Transplantation volume 45, pages 311–316 (2010)Cite this article

Abstract

Peripheral T-cell lymphoma (PTCL) is generally characterized by poor prognosis after conventional chemotherapy compared with aggressive B-cell lymphoma. To elucidate the role of high-dose chemotherapy (HDCT) with auto-SCT, we retrospectively analyzed the outcomes of 39 patients with PTCL who received HDCT and auto-SCT between 1990 and 2005. Eleven patients were histologically typed as angioimmunoblastic, nine as anaplastic large-cell lymphoma, seven as natural killer/T-cell lymphoma and twelve as PTCL unspecified. Clinical conditions at transplantation were complete response (CR) in 27 patients and non-CR in 12 patients. Thirty-two patients received a pre-transplant conditioning regimen (MCEC) comprising ranimustine, carboplatin, etoposide and CY, and seven did other TBI-based regimens. Rapid engraftment was obtained in all cases, and transplant-related death was not seen. An estimated 5-year OS was 62.1% with a median follow-up of 78 months. The 5-year OS was significantly higher in patients transplanted during complete response than in those during other disease status (71.4% vs 27.3%, P=0.046). HDCT supported by auto-SCT may therefore be effective as consolidation in CR for PTCL treatment.

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Acknowledgements

We thank the medical and nursing staff working at the Fukuoka Blood and Marrow Transplantation Group for providing information on the patients.

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Authors and Affiliations

  1. Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan

    A Numata, K Takase, H Henzan & T Eto

  2. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    T Miyamoto, K Kamezaki, T Tanimoto, K Kato, K Takenaka, T Fukuda, N Harada, K Nagafuji & K Akashi

  3. Department of Internal Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, Japan

    Y Ohno

  4. Department of Hematology, Harasanshin Hospital, Fukuoka, Japan

    T Kamimura

  5. Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan

    T Fukuda

  6. Division of Hematology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    K Nagafuji

  7. Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan

    T Teshima

  8. Ohmuta National Hospital, Ohmuta, Japan

    M Harada

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  1. A Numata
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for the Fukuoka Blood and Marrow Transplantation Group

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Correspondence to A Numata.

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Numata, A., Miyamoto, T., Ohno, Y. et al. Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group. Bone Marrow Transplant 45, 311–316 (2010). https://doi.org/10.1038/bmt.2009.165

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  • DOI: https://doi.org/10.1038/bmt.2009.165

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