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Thymoglobulin, CYA and mycophenolate mofetil as GVHD prophylaxis for reduced-intensity unrelated donor hematopoietic cell transplantation: beneficial effect seen on chronic GVHD

Bone Marrow Transplantation volume 45, pages 205–207 (2010)Cite this article

GVHD is a major cause of mortality following unrelated donor (URD) hematopoietic cell transplantation. As standard regimens using CYA or tacrolimus in combination with MTX are associated with rates of acute and chronic GVHD greater than 50%, improving GVHD prophylactic regimens remains a major challenge to successful hematopoietic cell transplantation.

In the late 1990s, the synergistic combination of CSA and mycophenolate mofetil (MMF) was developed at the Fred Hutchinson Cancer Center, with encouraging results in the non-myeloablative setting.1 However, a study conducted at the City of Hope Cancer Center using CSA and MMF in patients who had undergone reduced-intensity URD hematopoietic cell transplantation showed high rates of both acute and chronic GVHD.2 In an attempt to improve on our earlier experience, and based on emerging data using thymoglobulin,3, 4 we conducted a prospective clinical trial using thymoglobulin added to CSA/MMF as GVHD prophylaxis.

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Authors and Affiliations

  1. Department of Hematology/Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    R Rodriguez, A Nademanee, P Parker, R Nakamura, D Snyder, V Pullarkat, J Zain, E Smith, K Patane, D Senitzer & S J Forman

  2. Department of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    J M Palmer

  3. The City of Hope-Southern California Kaiser Permanente Bone Marrow Transplant Program, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    F Sahebi

  4. Department of Anatomic Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    K Chang

  5. Southern California Permanente Medical Group, Los Angeles, CA, USA

    R Rodriguez

Authors
  1. R Rodriguez
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  2. A Nademanee
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  3. J M Palmer
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  4. P Parker
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  7. V Pullarkat
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  8. J Zain
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  9. E Smith
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  10. F Sahebi
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  11. K Patane
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  12. D Senitzer
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  13. K Chang
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  14. S J Forman
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Corresponding author

Correspondence to S J Forman.

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Rodriguez, R., Nademanee, A., Palmer, J. et al. Thymoglobulin, CYA and mycophenolate mofetil as GVHD prophylaxis for reduced-intensity unrelated donor hematopoietic cell transplantation: beneficial effect seen on chronic GVHD. Bone Marrow Transplant 45, 205–207 (2010). https://doi.org/10.1038/bmt.2009.112

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  • DOI: https://doi.org/10.1038/bmt.2009.112

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