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Post-Transplants Events

Subsets of CD34+ and early engraftment kinetics in allogeneic peripheral SCT for AML

Bone Marrow Transplantation volume 41, pages 977–981 (2008)Cite this article

Abstract

This study aimed to identify which graft product subset of CD34+ cells might be the most predictive of early hematopoietic recovery following allogeneic peripheral SCT (allo-PBSCT). The relationship between the number of ‘mature’ subsets of CD34+ cells (CD34+/CD33+, CD34+/CD38+, CD34+/DR+ and CD34+/CD133−) and ‘immature’ subsets of CD34+ cells (CD34+/CD33−, CD34+/CD38−, CD34+/DR− and CD34+/CD133+) and early neutrophil and platelet engraftment were studied in a homogeneous series (for disease, pre transplant chemotherapy, conditioning regimen and GVHD prophylaxis) of 30 AML patients after allo-PBSCT from HLA-identical siblings. In our experience, the total CD34+/CD133+ cell number was inversely correlated with the days required for the recovery of 0.5 × 109/l neutrophils (r=−0.82, P=0.02) and platelets of 20 × 109/l (r=−0.60, P=0.06); this correlation was better than the total CD34+ cell dose and neutrophil (r=−0.70, P=0.04) and platelet engraftment (r=−0.56, P=0.07). We suggest that a high number of CD34+/CD133+ PBSC may be associated with faster neutrophil and platelet recovery; these findings may help to predict the repopulating capacity of PBSC in patients after allo-PBSCT, especially when a relatively low number of CD34+ cells is infused.

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Acknowledgements

This work was supported by the Fondazione Cassa di Risparmio di Puglia ‘Progetto integrato per la salvaguardia della salute dell'uomo’. We thank Ms MVC Pragnell BA for language assistance in the preparation of the manuscript.

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  1. Hematology Section, DAP, University of Bari, Bari, Italy

    D Pastore, A Mestice, T Perrone, F Gaudio, M Delia, F Albano, A Russo Rossi, P Carluiccio, M Leo, V Liso & G Specchia

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  1. D Pastore
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Correspondence to G Specchia.

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Pastore, D., Mestice, A., Perrone, T. et al. Subsets of CD34+ and early engraftment kinetics in allogeneic peripheral SCT for AML. Bone Marrow Transplant 41, 977–981 (2008). https://doi.org/10.1038/bmt.2008.87

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