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Blood eosinophilia after unrelated cord blood transplantation for adults

Bone Marrow Transplantation volume 42, pages 63–65 (2008)Cite this article

Blood eosinophilia occurs under various conditions, such as infection, drug administration and autoimmune disease (secondary) or with hematological malignancy (clonal).1 Eosinophilia also occurs after hematopoietic SCT; however, the majority of patients studied were BMT recipients. Here, we studied on eosinophilia in 101 adults after umbilical cord blood transplantation (CBT).

The association of possible risk factors for developing eosinophilia after CBT was studied using Fisher’s exact test. Age (less than 40 versus 40 years or more), gender (male versus female), disease status (low risk versus high risk), total nucleated cell dose (less than 2.5 × 107 versus 2.5 × 107/kg or more), CD34-positive cell dose (less than 1.0 × 105 versus 1.0 × 105/kg or more) and HLA-matching (5- or 4-match versus 3- or 2-match) were not associated with the incidence of mild-to-severe or moderate-to-severe eosinophilia (data not shown). Unexpectedly, pretransplant CMV-seropositivity was associated with a lower incidence of moderate-to-severe eosinophilia after CBT (17.6 versus 56.2%, P=0.0004), but not mild-to-severe eosinophilia (72.9 versus 81.2%, P=0.10). The main reason for the association between pretransplant CMV seropositivity and less occurrence of moderate-to-severe eosinophilia after CBT is probably the myelotoxic effect of ganciclovir therapy against CMV infection.3

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Acknowledgements

We thank Maki Monna-Oiwa for her secretarial assistance. We also thank the Kobayashi Foundation for financial support.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    A Tomonari, S Takahashi, J Ooi, N Tsukada, T Konuma, S Kato, S Kasahara, T Iseki, A Tojo & S Asano

  2. Integrative Bioscience and Biomedical Engineering, School of Science and Engineering, Waseda University, Tokyo, Japan E-mail: atomonar@ims.u-tokyo.ac.jp,

    S Asano

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  1. A Tomonari
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Tomonari, A., Takahashi, S., Ooi, J. et al. Blood eosinophilia after unrelated cord blood transplantation for adults. Bone Marrow Transplant 42, 63–65 (2008). https://doi.org/10.1038/bmt.2008.78

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