Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Infectious Diseases

Bacteremias in children receiving hemopoietic SCT

Bone Marrow Transplantation volume 41, pages S104–S106 (2008)Cite this article

Abstract

The incidence of bacteremia following hemopoietic SCT (HSCT) changes over time from the procedure. The first 30 days have the highest incidence, both in autologous and allogeneic HSCT recipients. In the following periods, bacteremia is a frequent complication in allogeneic HSCT, especially from alternative donors. Gram-positive cocci represent the most frequent cause of single-agent bacteremia. Knowledge of epidemiology (incidence and etiology) of bacteremias following HSCT is pivotal for planning management strategies (prevention, diagnosis and therapy) that must be distinct in the different post-transplant period.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Ninin E, Milpied N, Moreau P, André-Richet B, Morineau N, Mahé B et al. Longitudinal study of bacterial, viral, and fungal infections in adult recipients of bone marrow transplants. Clin Infect Dis 2001; 33: 41–47.

    Article  CAS  Google Scholar 

  2. Romano V, Castagnola E, Dallorso S, Lanino E, Calvi A, Silvestro S et al. Bloodstream infections can develop late (after day 100) and/or in the absence of neutropenia in children receiving allogeneic bone marrow transplantation. Bone Marrow Transplant 1999; 23: 271–275.

    Article  CAS  Google Scholar 

  3. Benjamin DK, Miller WC, Bayliff S, Martel L, Alexander KA, Martin PL et al. Infections diagnosed in the first year after pediatric stem cell transplantation. Pediatr Infect Dis J 2002; 21: 227–234.

    Article  Google Scholar 

  4. Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 2001; 19: 2201–2205.

    Article  CAS  Google Scholar 

  5. Sepkowitz KA . Risk and epidemiology of infections after allogeneic hemopoietic stem cell transplantation. In: Bowden RA, Ljungman P, Paya CV, (eds). Transplant Infections. Lippincott Willians & Wilkins: Philadelphia, 2003, pp 31–38.

    Google Scholar 

  6. Anaissie E, Nucci M . Risk and epidemiology of infections after autologous hemopoietic stem cell transplantation. In: Bowden RA, Ljungman P, Paya CV, (eds). Transplant Infections. Lippincott Willians & Wilkins: Philadelphia, 2003, pp. 39–50.

    Google Scholar 

  7. Castagnola E, Conte M, Parodi S, Papio F, Caviglia I, Haupt R . Incidence of bacteremias and invasive mycoses in children with high risk neuroblastoma. Pediatr Blood Cancer 2007; 49: 672–677.

    Article  Google Scholar 

  8. Barker JN, Hough RE, van Burik JA, DeFor TE, MacMillan ML, O’Brien MR et al. Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source. Biol Blood Marrow Transplant 2005; 11: 362–370.

    Article  Google Scholar 

  9. Nagatoshi Y, Kawano Y, Okamura J . Comparison of the outcomes of allogeneic bone marrow transplantation from partially mismatched related donors, matched sibling donors, and matched unrelated donors in Japanese pediatric patients: a single center result. Pediatr Transplant 2004; 8: 260–266.

    Article  Google Scholar 

  10. Nucci M, Andrade F, Vigorito A, Trabasso P, Aranha JF, Maiolino A et al. Infectious complications in patients randomized to receive allogeneic bone marrow or peripheral blood transplantation. Transpl Infect Dis 2003; 5: 167–173.

    Article  CAS  Google Scholar 

  11. van Kraaij MG, Verdonck LF, Rozenberg-Arska M, Dekker AW . Early infections in adults undergoing matched related and matched unrelated/mismatched donor stem cell transplantation: a comparison of incidence. Bone Marrow Transplant 2002; 30: 303–309.

    Article  CAS  Google Scholar 

  12. Castagnola E, Molinari AC, Fratino G, Viscoli C . Conditions associated with infections of indwelling central venous catheters in cancer patients: a summary. Br J Haematol 2003; 121: 233–239.

    Article  Google Scholar 

  13. Fratino G, Molinari AC, Parodi S, Longo S, Saracco P, Castagnola E et al. Central venous catheter-related complications in children with oncological/hematological diseases: an observational study of 418 devices. Ann Oncol 2005; 16: 648–654.

    Article  CAS  Google Scholar 

  14. Viscoli C, Castagnola E . Prophylaxis and empirical therapy for infection in cancer patients. In: Mandell GL, Bennett JE, Doolin R, (eds). Principles and Practice of Infectious Diseases. Churchill Livingstone: Philadelphia, 2005, pp 3442–3462.

    Google Scholar 

  15. Viscoli C, Castagnola E, Giacchino M, Cesáro S, Properzi E, Tucci F et al. Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology. Supportive Therapy Group–Infectious Diseases Section. Eur J Cancer 1999; 35: 770–774.

    Article  CAS  Google Scholar 

  16. Engelhard D, Geller N, Paterson DL . Gram-positive and Gram-negative infections after hemopoietic stem cell or solid organ transplantation. In: Bowden RA, Ljungman P, Paya CV, (eds). Transplant Infections. Lippincott Willians & Wilkins: Philadelphia, 2003, pp 225–249.

    Google Scholar 

  17. Engelhard D, Cordonnier C, Shaw PJ, Parkalli T, Guenther C, Martino R et al. Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey. Br J Haematol 2002; 117: 444–450.

    Article  Google Scholar 

  18. Bucaneve G, Micozzi A, Menichetti F, Martino P, Dionisi MS, Martinelli G et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005; 353: 977–987.

    Article  CAS  Google Scholar 

  19. Leibovici L, Paul M, Cullen M, Bucaneve G, Gafter-Gvili A, Fraser A et al. Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions. Cancer 2006; 107: 1743–1751.

    Article  CAS  Google Scholar 

  20. Castagnola E, Fioredda F . Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: a brief review of current recommendations for practical purposes. Eur J Haematol 2003; 71: 319–326.

    Article  Google Scholar 

  21. Ljungman P, Engelhard D, de la Cámara R, Einsele H, Locasciulli A, Martino R et al. Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT. Bone Marrow Transplant 2005; 35: 737–746.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, Infectious Diseases Unit, G Gaslini Children's Hospital, Genoa, Italy

    E Castagnola, C Moroni, I Caviglia & A R Natalizia

  2. Department of Hematology and Oncology, Bone Marrow Transplant Unit, G Gaslini Children's Hospital, Genoa, Italy

    M Faraci, V de Fazio, G Morreale, E Lanino & G Dini

  3. Laboratory of Microbiology, G Gaslini Children's Hospital, Genoa, Italy

    R Bandettini

  4. Epidemiology and Biostatistics Section, Scientific Directorate, G Gaslini Children's Hospital, Genoa, Italy

    S Caruso, F Bagnasco & R Haupt

Authors
  1. E Castagnola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Faraci
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C Moroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R Bandettini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Caruso
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Bagnasco
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I Caviglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A R Natalizia
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. V de Fazio
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. G Morreale
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. E Lanino
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G Dini
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. R Haupt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Castagnola.

Additional information

Conflict of interest

None of the authors declared any financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castagnola, E., Faraci, M., Moroni, C. et al. Bacteremias in children receiving hemopoietic SCT. Bone Marrow Transplant 41 (Suppl 2), S104–S106 (2008). https://doi.org/10.1038/bmt.2008.66

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2008.66

Keywords

This article is cited by

Search

Advanced search

Quick links