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The effect of administration order of BU and CY on toxicity in hematopoietic SCT in humans

Bone Marrow Transplantation volume 43, pages 883–885 (2009)Cite this article

We read with interest the paper from Sadeghi et al.1 recently published in your journal. The authors studied the effect of administration order of BU and CY as a conditioning regimen for hematopoietic SCT (HSCT) in a mouse model. They showed that inverting the order of BU–CY to CY–BU not only decreased conditioning-related toxicity significantly, but also allowed the same level of donor hematopoietic stem cell (HSC) engraftment. These data support earlier studies showing a potential benefit of CY–BU in animal models, and do encourage further investigation in humans.2

To test the possible effect on liver toxicity and clinical outcome of this approach, we started a clinical trial using CY–BU as a myeloablative conditioning regimen for HSCT in 2005.

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References

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Authors and Affiliations

  1. Bone Marrow Transplantation Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

    F R Kerbauy, B Tirapelli, H Akabane & J S R Oliveira

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  1. F R Kerbauy
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  2. B Tirapelli
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  3. H Akabane
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  4. J S R Oliveira
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Correspondence to F R Kerbauy.

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Kerbauy, F., Tirapelli, B., Akabane, H. et al. The effect of administration order of BU and CY on toxicity in hematopoietic SCT in humans. Bone Marrow Transplant 43, 883–885 (2009). https://doi.org/10.1038/bmt.2008.404

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