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Allogeneic hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor

Bone Marrow Transplantation volume 43, pages 589–590 (2009)Cite this article

Continuous immunosuppressive treatment after solid organ transplantation is associated with an increased incidence of therapy-related AML (t-AML).1 The prognosis of t-AML is poor and the treatment with the highest potential for cure is allogeneic hematopoietic cell transplantation (Allo-HCT).2, 3 We report the first case of Allo-HCT for t-AML that developed after liver transplantation (LTX) from the identical donor.

Currently, published reports include cases of sibling Allo-HCT after unrelated cadaveric LTX for aplastic anemia,7 matched unrelated Allo-HCT after cadaveric LTX in a patient with hyperimmunoglobulin M syndrome,8 combined transplantation of BM and liver from a cadaveric donor for liver cancer9 and Allo-HCT after orthotopic LTX for hemophagocytic lymphohistiocytosis.10 These cases differ significantly from ours as the underlying diseases did not develop after LTX. The reported case indicates that haploidentical Allo-HCT as a treatment for t-AML developing under immunosuppression is feasible and can induce durable remission. However, opportunistic infections have to be monitored carefully based on the profound immune defect in this situation.

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Author notes

  1. R Zeiser and A Zerweck: These authors contributed equally to this work.

Authors and Affiliations

  1. Department Division of Hematology and Oncology, of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany

    R Zeiser, A Zerweck, H Bertz & J Finke

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  1. R Zeiser
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  2. A Zerweck
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  3. H Bertz
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  4. J Finke
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Correspondence to J Finke.

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Zeiser, R., Zerweck, A., Bertz, H. et al. Allogeneic hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor. Bone Marrow Transplant 43, 589–590 (2009). https://doi.org/10.1038/bmt.2008.361

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