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Plasma exchange after hematopoietic stem cell transplantation in multiple myeloma to reduce renal insufficiency

Bone Marrow Transplantation volume 42, page 767 (2008)Cite this article

Hematopoietic cell transplantation (HCT) has been associated with the development of both acute and chronic kidney failure.1 Although the requirement for dialysis following HCT is relatively uncommon (in the 2–5% range), it is associated with poor prognosis. The incidence of acute renal failure (defined as a >50% reduction in glomerular filtration rate) for those undergoing myeloablative autologous hematopoietic stem cell transplantation (AHSCT) has been reported as high as 20%.2 Peripheral blood progenitor cells are cryopreserved using the cryoprotectant dimethyl sulfoxide (DMSO). Infusion of peripheral blood progenitor cells cryopreserved with DMSO has been associated with toxicities such as acute renal failure.3 It has been reported that adverse events following infusions of cryopreserved hematopoietic stem cells is associated with the concentration of red blood cells in the infused specimen.4

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  1. Department of Medicine, Section of Hematology and Medical Oncology, St Vincent's Hospital and Comprehensive Cancer Center, New York, NY, USA

    K Sullivan, S Jagannath, A Mazumder & D H Vesole

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  1. K Sullivan
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  2. S Jagannath
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  3. A Mazumder
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  4. D H Vesole
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Correspondence to D H Vesole.

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Sullivan, K., Jagannath, S., Mazumder, A. et al. Plasma exchange after hematopoietic stem cell transplantation in multiple myeloma to reduce renal insufficiency. Bone Marrow Transplant 42, 767 (2008). https://doi.org/10.1038/bmt.2008.245

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  • DOI: https://doi.org/10.1038/bmt.2008.245

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