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Allogeneic donor bone marrow cells recovery and infusion after allogeneic face transplantation from the same donor

Bone Marrow Transplantation volume 41, pages 1059–1061 (2008)Cite this article

An Erratum to this article was published on 23 July 2008

Immunological obstacles to composite tissue allotransplantation can be overcome with immunosuppressive drugs.1 However, regarding the risk of chronic rejection the long-term outcome of tissue composite transplant is not known. The decision to include BM cell infusions in the first human facial allotransplantation was based on studies where immunosuppression combined with the infusion of donor BM cells after graft organs led to a decrease in chronic rejection and an improvement of long-term graft survival.2 However, the number of BM cells and preparative conditioning regimen required to induce tolerance of transplant organ have not been determined yet. We are reporting the results of BM infusion associated with a facial transplantation and discussing the characteristics of these cells and their potential role.

The patient, a 38-year-old woman, was bitten by her dog on the face generating severe tissue amputations as described previously.3 Although human face transplantation was being discussed, the transplantation team decided to infuse BM recovered from the same donor.

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Authors and Affiliations

  1. Laboratory of Cellular Therapy, EFS, Edouard Herriot Hospital, Lyon, France

    O Hequet & J-P Bourgeot

  2. Department of Hematology, Edouard Herriot Hospital, Lyon, France

    M Michallet

  3. Department of Transplantation, Edouard Herriot Hospital, UCLB1, Lyon, France

    E Morelon & J-M Dubernard

  4. HLA Laboratory, EFS, Lyon, France

    V Dubois

  5. Department of Facial Surgery, Amiens Picardie Hospital, Amiens, France

    B Devauchelle

Authors
  1. O Hequet
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  2. J-P Bourgeot
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  3. M Michallet
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  4. E Morelon
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  5. J-M Dubernard
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  6. V Dubois
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  7. B Devauchelle
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Correspondence to O Hequet.

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Hequet, O., Bourgeot, JP., Michallet, M. et al. Allogeneic donor bone marrow cells recovery and infusion after allogeneic face transplantation from the same donor. Bone Marrow Transplant 41, 1059–1061 (2008). https://doi.org/10.1038/bmt.2008.23

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