Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation


The National Marrow Donor Program® (NMDP) is headquartered in Minneapolis, Minnesota, USA. Established in 1986, the NMDP currently operates the world's largest registry of unrelated adult donors and umbilical cord blood (UCB) units. Since its inception, the NMDP has benefited from continuous financial support provided by the US government through a series of contracts and grant awards. This funding has supported a large network of donor centers and the recruitment of millions of potential adult hematopoietic cell (HC) donors. More recently, the federal government has also supported a national registry for UCB units and expansion of the available UCB inventories. Today, the NMDP registry lists more than 6.7 million adult donors and 68 000 UCB units. Seventy-seven percent (5.2 million) of the adult donors and virtually all of the UCB units are fully typed for HLA A, B and DR. An additional 5 million donors are available for search through international collaborations. The NMDP currently facilitates more than 3600 recipients each year totaling more than 29 000 transplants since 1987.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others


  1. McCullough J, Perkins HA, Hansen J . The National Marrow Donor Program with emphasis on the early years. Transfusion 2006; 46: 1248–1255.

    Article  Google Scholar 

  2. Bone Marrow Donors Worldwide. Leiden, The Netherlands; 2007.

  3. Gahrton G, van Rood JJ, Oudshoorn M, World Marrow Donor A . The world marrow donor association (WMDA): its goals and activities. Bone Marrow Transplant 2003; 32: 121–124.

    Article  CAS  Google Scholar 

  4. Goldman JM, Cleaver S, Warren P . World Marrow Donor Association: a progress report. Bone Marrow Transplant 1994; 13: 689–691.

    CAS  PubMed  Google Scholar 

  5. Stem Cell Trialists' Collaborative G. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials. J Clin Oncol 2005; 23: 5074–5087.

    Article  Google Scholar 

  6. Eapen M, Logan BR, Confer DL, Haagenson M, Wagner JE, Weisdorf DJ et al. Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. Biol Blood Marrow Transplant 2007; 13: 1461–1468.

    Article  Google Scholar 

  7. Eapen M, Horowitz MM, Klein JP, Champlin RE, Loberiza Jr FR, Ringden O et al. Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: the Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry. J Clin Oncol 2004; 22: 4872–4880.

    Article  Google Scholar 

  8. Hurley CK, Lowe LAB, Logan B, Karanes C, Anasetti C, Weisdorf D et al. National marrow donor program HLA-matching guidelines for unrelated marrow transplants. Biol Blood Marrow Transplant 2003; 9: 610–615.

    Article  Google Scholar 

  9. Maiers M, Gragert L, Klitz W . High-resolution HLA alleles and haplotypes in the United States population. Human Immunol 2007; 68: 779–788.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to P Robinett.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Confer, D., Robinett, P. The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation. Bone Marrow Transplant 42 (Suppl 1), S3–S5 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:


This article is cited by


Quick links