Figure 1

From: Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence

Figure 1

Bioinformatic analysis reveals the potential use of MYO5B as a diagnostic marker for CRC. (A) Dot plot showing the log2 FC values of the Myosin V family genes in adenoma (beige) and CRC (blue) samples compared to healthy colorectal mucosa samples (grey) in a meta-analysis of different CRC data sets, including 829 patients. Bar represents the mean expression intensity (***P<0.001, t-test corrected for multiple testing). (B) MYO5B expression according to the different TNM stages in the meta-analysis. Bar represents the mean expression intensity (*P<0.05, ***P<0.001, t-test corrected for multiple testing). (C) ROC curves with corresponding AUC values for MYO5A, MYO5B, and MYO5C when comparing CRC and healthy samples in the meta-analysis. Distribution of gene expression values for healthy and CRC samples are shown in the insets.