Table 4 Adjusted HRa and 95% CI for associations between average BMI, and oesophageal and gastric cardia adenocarcinoma incidence, NIH-AARP Diet and Health Study, and PLCO Cancer Screening Trial

From: Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

   Oesophageal adenocarcinoma Gastric cardia adenocarcinoma
Average BMI, kg m −2 Non-cases ( n) Cases ( n) HR (95% CI) Cases ( n) HR (95% CI)
Age 20 and 50
<18.5 5243 4 2
18.5–<25 276 661 357 Referent 249 Referent
25–<30 93 555 208 1.45 (1.22, 1.72) 105 1.11 (0.88, 1.39)
30 16 706 35 1.80 (1.27, 2.56) 29 2.21 (1.50, 3.26)
Continuous, kg m −2    1.08 (1.05, 1.10)   1.06 (1.03, 1.10)
P for trend    <0.0001   0.0002
Age 20 and baseline
<18.5 3405 1 0
18.5–<25 247 837 307 Referent 206 Referent
25–<30 117 325 232 1.39 (1.17, 1.65) 141 1.31 (1.06, 1.63)
30 23 598 64 2.51 (1.91, 3.31) 38 2.26 (1.59, 3.21)
Continuous, kg m −2    1.09 (1.07, 1.12)   1.08 (1.05, 1.11)
P for trend    <0.0001   <0.0001
Age 50 and baseline
<18.5 2064 0 1
18.5–<25 156 220 146 Referent 102 Referent
25–<30 168 461 301 1.40 (1.15, 1.71) 201 1.41 (1.11, 1.80)
30 65 420 157 2.38 (1.89, 3.00) 81 1.81 (1.34, 2.43)
Continuous, kg m −2    1.08 (1.06, 1.10)   1.06 (1.04, 1.09)
P for trend    <0.0001   <0.0001
  1. Abbreviations: BMI=body mass index; CI=confidence interval; HR=hazard ratio; PLCO=Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  2. aAdjusted for sex, race (non-Hispanic white, non-Hispanic black, other), smoking (never/current/former, and categorised cigarettes per day (0, 1–10, 11–20, 21–30, 31–40, 41–60, 61+)), education (high school or less, technical school or some college, college graduate, postgraduate), and study. HRs suppressed for cells with 5 cases.