Table 2 Adjusted HRa and 95% CI for associations between age-specific BMI, and oesophageal and gastric cardia adenocarcinoma incidence, NIH-AARP Diet and Health Study, and PLCO Cancer Screening Trial

From: Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

   Oesophageal adenocarcinoma Gastric cardia adenocarcinoma
  Non-cases ( n) Cases ( n) HR (95% CI) Cases ( n) HR (95% CI)
BMI, age 20
<18.5 49 308 55 0.76 (0.58, 1.01) 46 0.99 (0.72, 1.36)
18.5–<25 293 394 433 Referent 270 Referent
25–<30 42 758 102 1.31 (1.06, 1.63) 63 1.39 (1.05, 1.83)
30 6705 14 1.44 (0.85, 2.46) 6 1.02 (0.45, 2.29)
Continuous, kg m −2    1.05 (1.03, 1.08)   1.04 (1.01, 1.07)
P for trend    <0.0001   0.01
BMI, age 50
<18.5 2925 2 3
18.5–<25 182 400 183 Referent 124 Referent
25–<30 154 970 298 1.34 (1.11, 1.61) 197 1.39 (1.11, 1.75)
30 51 870 121 2.09 (1.66, 2.65) 61 1.63 (1.19, 2.23)
Continuous, kg m −2    1.06 (1.04, 1.08)   1.05 (1.02, 1.08)
P for trend    <0.0001   <0.0001
BMI, baseline
<18.5 2608 1 1
18.5–<25 136 082 126 Referent 90 Referent
25–<30 167 025 280 1.32 (1.07, 1.63) 176 1.22 (0.94, 1.58)
30 86 450 197 2.21 (1.76, 2.77) 118 1.89 (1.43, 2.50)
Continuous, kg m −2    1.07 (1.05, 1.09)   1.06 (1.04, 1.08)
P for trend    <0.0001   <0.0001
BMI, maximum b
<18.5 1069 1 3
18.5–<25 53 686 50 Referent 43 Referent
25–<30 112 729 188 1.17 (0.85, 1.60) 124 0.97 (0.68, 1.38)
30 84 766 191 1.74 (1.27, 2.40) 115 1.31 (0.91, 1.87)
Continuous, kg m −2    1.04 (1.03, 1.06)   1.03 (1.01, 1.06)
P for trend    <0.0001   0.004
Time BMI first exceeded 25.0 kg m −2
Never 121 560 110 Referent 79 Referent
Age 20 49 463 116 1.76 (1.35, 2.29) 69 1.62 (1.16, 2.25)
Age 50 162 667 308 1.47 (1.18, 1.83) 191 1.34 (1.03, 1.76)
Baseline age 58 475 70 1.13 (0.83, 1.52) 46 1.04 (0.72, 1.50)
  1. Abbreviations: BMI=body mass index; CI=confidence interval; HR=hazard ratio; PLCO=Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  2. aAdjusted for sex, race (non-Hispanic white, non-Hispanic black, other), smoking (never/current/former, and categorised cigarettes per day (0, 1–10, 11–20, 21–30, 31–40, 41–60, 61+)), education (high school or less, technical school or some college, college graduate, postgraduate), and study. HRs suppressed for cells with 5 cases.
  3. bOnly asked of NIH-AARP participants.