Table 1 Demographic and tumour characteristics of prostate cancer patients at baseline by ADT exposure

From: Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study

  ADT not used ( N =5467) ADT used ( N =2170) Total ( N =7637) P-value
Age, years
65 2072 (37.9) 430 (19.8) 2502 (32.8) <0.0001
>65 3395 (62.1) 1740 (80.2) 5135 (67.2)  
Charlson score 1 year before PC diagnoses
0 2716 (60.3) 826 (52.7) 3542 (58.4) <0.0001
1–2 1426 (31.7) 584 (37.3) 2010 (33.1)  
3+ 361 (8.0) 157 (10.0) 518 (8.5)  
Missing 964 603 1567  
Race/ethnicity
Hispanic 793 (14.5) 312 (14.4) 1105 (14.5) 0.0097
White 3356 (61.4) 1292 (59.5) 4648 (60.9)  
African-American 856 (15.7) 405 (18.7) 1261 (16.5)  
Asian 462 (8.5) 161 (7.4) 623 (8.2)  
Hypertension
No 2237 (40.9) 789 (36.4) 3026 (39.6) 0.0002
Yes 3230 (59.1) 1381 (63.6) 4611 (60.4)  
Diabetes
No 4572 (83.6) 1729 (79.7) 6301 (82.5) <0.0001
Yes 895 (16.4) 441 (20.3) 1336 (17.5)  
Year of PC diagnosis
1998–2000 1256 (23.0) 826 (38.1) 2082 (27.3) <0.0001
2001–2005 2465 (45.1) 899 (41.4) 3364 (44.0)  
2006+ 1746 (31.9) 445 (20.5) 2191 (28.7)  
Stage at diagnosis
T1 3726 (69.1) 1196 (55.8) 4922 (65.3) <0.0001
T2 1600 (29.7) 837 (39.0) 2437 (32.3)  
T3 69 (1.3) 112 (5.2) 181 (2.4)  
Missing 72 25 97  
Gleason score
<7 3388 (69.0) 851 (42.3) 4239 (61.2) <0.0001
7 1088 (22.1) 631 (31.4) 1719 (24.8)  
>7 437 (8.9) 528 (26.3) 965 (13.9)  
Missing 554 160 714  
Risk groups
Low 2218 (47.7) 389 (19.2) 2607 (39.1) <0.0001
Intermediate 1398 (30.1) 637 (31.5) 2035 (30.5)  
High 1030 (22.2) 997 (49.3) 2027 (30.4)  
Missing 821 147 968  
Preexisting CVD
No 4290 (78.5) 1682 (77.5) 5972 (78.2) 0.3598
Yes 1177 (21.5) 488 (22.5) 1665 (21.8)  
Smoking status a
Current 451 (12.8) 190 (12.9) 641 (12.8) 0.0078
Former 1472 (41.7) 680 (46.1) 2152 (43.0)  
Never 1611 (45.6) 605 (41.0) 2216 (44.2)  
Missing 1933 695 2628  
BMI b
Underweight or normal 498 (30.0) 172 (38.0) 670 (31.7) 0.0098
Overweight 729 (43.9) 181 (40.0) 910 (43.0)  
Obese 435 (26.2) 100 (22.1) 535 (25.3)  
  1. Abbreviations: ADT=androgen deprivation therapy; BMI=body mass index; CVD=cardiovascular disease; PC=prostate cancer.
  2. P-value based on Pearson’s chi-square test, two-sided.
  3. a35% was missing, smoking history was not available in EMR until 2004.
  4. b72% missing, BMI was not available in EMR until 2006.