Table 4 Adjusted odds ratio for tonsillectomy and oropharyngeal subsite and HPV/p16 status compared with controlsa

From: Previous tonsillectomy modifies odds of tonsil and base of tongue cancer

  Base of tongue/HPV+ Base of tongue/HPV Tonsil/HPV+ Tonsil/HPV
  OR (95% CI) P N (%) OR (95% CI) P N (%) OR (95% CI) P N (%) OR (95% CI) P N (%)
Tonsil removed
No Ref 17 (65.4%) Ref 21 (72.4%) Ref 99 (79.2%) Ref 32 (82.1%)
Yes 2.46 (1.22–4.95) 0.012 9 (34.6%) 1.24 (0.46–3.31) 0.671 8 (27.6%) 0.17 (0.08–0.34) <0.001 26 (20.8%) 0.66 (0.24–1.81) 0.415 7 (17.9%)
  Base of tongue/p16+ Base of tongue/p16 Tonsil/p16+ Tonsil/p16
Tonsil removed
No Ref 21 (44.7%) Ref 16 (66.7%) Ref 95 (92.2%) Ref 36 (81.8%)
Yes 2.24 (1.16–4.35) 0.017 26 (55.3%) 1.21 (0.43–3.36) 0.716 8 (33.3%) 0.14 (0.07–0.31) <0.001 8 (7.8%) 0.81 (0.31–2.10) 0.67 8 (18.2%)
  1. Abbreviations: CI=confidence interval; HPV=human papillomavirus; OR=odds ratio; Ref=reference value.
  2. aAdjusted for number of sexual partners, insurance, education, pack-years, alcohol, age, race, and gender.