Prognostic value of the enroled patients.(A) Flow diagram from chemotherapy to surgery for 73 eligible patients. *Patients with PR, SD or a histological response of Ib-3 according to the JCGC criteria. ** Patients with PD or a histological response of 0–Ia according to JCGC criteria. (B) Distribution of graded histologic regression for patients who underwent radical surgery. (C) Progression-free survival. (D) Overall survival. (E) OS according to ypTNM stage for those who underwent radical surgery. (F) OS according to graded histologic response (⩾50%/<50%).