Table 4 Risk classification model based on post-test probabilities for the presence of lung cancer

From: DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach

   Learning set Validation set P -value
  Lung cancer Control Lung cancer Control Lung cancer Control
RASSF1A 3OST2 and PRDM14 n /73 % n /86 % n /159 % n /154 %   
≥60%   29 39.7 2 2.3 54 34.0 15 9.7 0.56 0.04
  40–60% 11 15.1 2 2.3 29 18.2 0 0.0   
  20–40% 11 15.1 12 14.0 34 21.4 19 12.3   
  0–20% 22 30.1 70 81.4 42 26.4 120 77.9   
  1. RASSF1A was included as diagnostic marker to identify high-risk individuals (≥60% chance on lung cancer), 3OST2 and PRDM14 as risk marker for lower risk groups (40–60%, 20–40% and 0–20%, respectively).