Differential DNA denaturation PCR-derived CTNNB1 sequences from cirrhotic and normal liver DNA. (A) A collection of 3DPCR recovered CTNNB1 sequences from viral-associated liver cirrhosis. The amino-acid sequence is shown above where bold case identifies the residues that frequently are substituted in liver cancers. The annotation is as for Figure 1D. (B) Stack-up graph of the number of GC->AT transitions per sequence per liver sample. (C) Mutation frequencies per sample along with the absolute number of mutations and bases sequences (within parentheses). (D) 5′ Dinucleotide context of GC->AT transitions for G->A and C->T transitions respectively.