Table 2 Result of Cox regression analysis for patients’ features in those with NSCLC (n= 120 745)

From: Lung cancer survival in England: trends in non-small-cell lung cancer survival over the duration of the National Lung Cancer Audit

  No. of patients (%) No. of patients who died (%) Unadjusted HR (95% CI) Adjusted HR a (95% CI) P -value
Year
2004/2005 15 267 (12.64) 13 960 (91.44) 1 1  
2006 15 525 (12.86) 14 051 (90.51) 1.00 (0.98–1.03) 1.02 (0.99–1.04)  
2007 18 193 (15.07) 16 333 (89.78) 1.03 (1.00–1.05) 1.02 (1.00–1.04)  
2008 21 860 (18.10) 19 103 (87.39) 1.03 (1.01–1.05) 0.99 (0.97–1.01) <0.001b
2009 25 072 (20.76) 20 667 (82.43) 1.00 (0.98–1.02) 0.95 (0.93–0.97)  
2010 24 828 (20.56) 18 090 (72.86) 0.99 (0.97–1.02) 0.98 (0.96–1.00)  
Sex
Female 51 366 (42.54) 42 476 (82.69) 1 1  
Male 69 379 (57.46) 59 728 (86.09) 1.10 (1.09–1.12) 1.13 (1.12–1.14) <0.001
Age
<54 8097 (6.71) 6111 (75.47) 1 1  
55–59 8672 (7.18) 6935 (79.97) 1.12 (1.08–1.16) 1.12 (1.09–1.16)  
60–64 14 342 (11.88) 11 475 (80.01) 1.15 (1.12–1.19) 1.19 (1.16–1.23)  
65–69 17 846 (14.78) 14 511 (81.31) 1.22 (1.18–1.25) 1.25 (1.21–1.29)  
70–74 20 715 (17.16) 17 462 (84.30) 1.35 (1.31–1.39) 1.35 (1.31–1.39) <0.001b
75–79 21 897 (18.13) 19 087 (87.17) 1.51 (1.47–1.55) 1.45 (1.40–1.49)  
80–84 17 375 (14.39) 15 658 (90.12) 1.73 (1.68–1.79) 1.55 (1.51–1.60)  
85+ 11 801 (9.77) 10 965 (92.92) 2.05 (1.99–2.11) 1.62 (1.57–1.68)  
Stage
IA–IB 12 156 (10.07) 6045 (49.73) 1 1  
IIA–IIB 5836 (4.83) 3751 (64.27) 1.54 (1.48–1.60) 1.54 (1.48–1.61)  
IIIA 8789 (7.28) 7042 (80.12) 2.35 (2.27–2.43) 2.33 (2.25–2.42)  
IIIB 14 209 (11.77) 12 754 (89.76) 3.30 (3.20–3.40) 3.20 (3.10–3.30) <0.001b
IV 38 546 (31.92) 36 600 (94.95) 5.27 (5.13–5.42) 4.58 (4.45–4.71)  
Missing 41 209 (34.13) 36 012 (87.39) 3.11 (3.03–3.20) 2.78 (2.70–2.86)  
Performance status
0 16 984 (14.07) 11 395 (67.09) 1 1  
1 27 134 (22.47) 21 775 (80.25) 1.49 (1.45–1.52) 1.28 (1.25–1.31)  
2 17 963 (14.88) 16 378 (91.18) 2.43 (2.38–2.49) 1.84 (1.80–1.89)  
3 16 051 (13.29) 15 462 (96.33) 4.01 (3.92–4.11) 2.72 (2.65–2.79) <0.001b
4 5320 (4.41) 5228 (98.27) 7.24 (7.00–7.48) 4.39 (4.24–4.54)  
Missing 37 293 (30.89) 31 966 (85.72) 1.83 (1.79–1.87) 1.55 (1.52–1.59)  
Ethnicity
White 90 367 (74.84) 76 992 (85.20) 1 1  
Black 872 (0.72) 688 (78.90) 0.81 (0.75–0.88) 0.80 (0.74–0.87)  
Asian 1182 (0.98) 892 (75.47) 0.72 (0.68–0.77) 0.68 (0.63–0.73)  
Mixed 178 (0.15) 142 (79.78) 0.83 (0.71–0.98) 0.88 (0.74–1.04) <0.001c
Other 673 (0.56) 537 (79.79) 0.86 (0.79–0.93) 0.80 (0.73–0.87)  
Missing 27 473 (22.75) 22 953 (83.55) 1.06 (1.05–1.08) 1.08 (1.06–1.10)  
Charlson index
0 47 870 (39.65) 38 513 (80.45) 1 1  
1 23 992 (19.87) 19 806 (82.55) 1.06 (1.05–1.08) 1.00 (0.99–1.02)  
2 & 3 20 319 (16.83) 17 046 (83.89) 1.14 (1.12–1.16) 1.01 (0.99–1.03) <0.001b
4+ 28 564 (23.66) 26 839 (93.96) 2.03 (2.00–2.06) 1.53 (1.50–1.55)  
Source of referral
Referral from GP 57 864 (47.92) 47 234 (81.63) 1 1  
Emergency admission 15 399 (12.75) 14 557 (94.53) 2.19 (2.15–2.23) 1.53 (1.50–1.56)  
Domiciliary visit 319 (0.26) 256 (80.25) 0.96 (0.85–1.09) 0.97 (0.86–1.10)  
Ref. from consultant 23 385 (19.37) 19 476 (83.28) 1.16 (1.14–1.18) 1.05 (1.03–1.06)  
Self-referral 174 (0.14) 146 (83.91) 1.11 (0.94–1.30) 0.98 (0.83–1.15)  
Other (private health care) 8289 (6.86) 6877 (82.97) 1.08 (1.05–1.10) 0.99 (0.97–1.02) <0.001c
Following A&E attendance 7340 (6.08) 6759 (92.08) 1.94 (1.89–1.99) 1.44 (1.40–1.48)  
General dental practice 45 (0.04) 44 (97.78) 1.65 (1.23–2.22) 1.46 (1.09–1.96)  
Community dental service 8 (0.01) 6 (75.00) 1.00 (0.45–2.23) 0.99 (0.44–2.20)  
Not known 7922 (6.56) 6849 (86.46) 1.15 (1.12–1.18) 1.07 (1.04–1.09)  
  1. Abbreviations: CI=confidence interval; HR=hazard ratio.
  2. aHR adjusted for all other variables in the table.
  3. bP-value for trends.
  4. cLog-likelihood ratio test.